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Titolo:
Relaxin secretion by human granulosa cell culture is predictive of in-vitro fertilization-embryo transfer success
Autore:
Stewart, DR; VandeVoort, CA;
Indirizzi:
UnivReprod Davis, Inst Toxicol & Environm Hlth, Dept Obstet & Gynecol, DivUniv Calif Davis Davis CA USA 95616 ronm Hlth, Dept Obstet & Gynecol, Div Univ Calif Davis, Calif Reg Primate Res Ctr, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 Primate Res Ctr, Davis, CA 95616 USA
Titolo Testata:
HUMAN REPRODUCTION
fascicolo: 2, volume: 14, anno: 1999,
pagine: 338 - 344
SICI:
0268-1161(199902)14:2<338:RSBHGC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
OVARIAN 11-BETA-HYDROXYSTEROID DEHYDROGENASE; PREGNANCY; STIMULATION; CONCEPTION; GLYCODELIN; MYOMETRIUM; CYCLES;
Keywords:
granulosa cell culture; infertility; in-vitro fertilization; pregnancy; relaxin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Stewart, DR UnivReprod Davis, Inst Toxicol & Environm Hlth, Dept Obstet & Gynecol, Div Univ Calif Davis Davis CA USA 95616 ept Obstet & Gynecol, Div
Citazione:
D.R. Stewart e C.A. VandeVoort, "Relaxin secretion by human granulosa cell culture is predictive of in-vitro fertilization-embryo transfer success", HUM REPR, 14(2), 1999, pp. 338-344

Abstract

We have developed a cell culture system for human luteinizing granulosa cells which supports the timely and dynamic secretion of oestrogen, progesterone and relaxin in patterns that mimic serum concentrations of these hormones during the luteal phase of the menstrual cycle. There was a wide variation in the amount of relaxin secreted by the cultured cells for the 69 patients studied. As relaxin production was generally maximal by day 10 of culture, comparisons were made at this time point. It was observed that most of the conceptions occurred in patients with higher relaxin secretion irt vitro. All cycles with relaxin >800 pg/ml on day 10 had a term pregnancy while only 13% of cycles with relaxin <200 pg/ml had term pregnancies. A limited number of cycles from donor/recipient cycles did not show similar results. Steroid concentrations were dot predictive of conception. These results demonstrated that in-vitro production of relaxin is predictive of implantationsuccess in in-vitro fertilization (IVF)-embryo transfer cycles. This supports the hypothesis that relaxin may be involved in implantation and that lowered relaxin concentrations may be a partial cause of poor pregnancy ratesafter IVF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 18:54:58