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Titolo:
Antitumor activity of curcumin is mediated through the induction of apoptosis in AK-5 tumor cells
Autore:
Khar, A; Ali, AM; Pardhasaradhi, BVV; Begum, Z; Anjum, R;
Indirizzi:
Ctr Cellular & Mol Biol, Hyderabad 500007, Andhra Pradesh, India Ctr Cellular & Mol Biol Hyderabad Andhra Pradesh India 500007 desh, India
Titolo Testata:
FEBS LETTERS
fascicolo: 1, volume: 445, anno: 1999,
pagine: 165 - 168
SICI:
0014-5793(19990219)445:1<165:AAOCIM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELL; RAT HISTIOCYTOMA; REGRESSION; LONGA; LIVER;
Keywords:
AK-5 apoptosis; curcumin; tumor growth; caspase-3;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Khar, A Ctr Cellular & Mol Biol, Uppal Rd, Hyderabad 500007, Andhra Pradesh, India Ctr Cellular & Mol Biol Uppal Rd Hyderabad Andhra Pradesh India 500007
Citazione:
A. Khar et al., "Antitumor activity of curcumin is mediated through the induction of apoptosis in AK-5 tumor cells", FEBS LETTER, 445(1), 1999, pp. 165-168

Abstract

Curcumin, the yellow pigment of turmeric (Curcuma longa), used commonly asa spice, has been shown to possess anticarcinogenic activity. Curcumin inhibited AK-5 tumor growth and induced apoptosis in AK-5 cells. Curcumin induced apoptosis is mediated through the activation of caspase-3, which is specifically inhibited by the tetrapeptide Ac-DEVD-CHO, In addition, curcumin induced tumor cell death is caused through the generation of reactive oxygen intermediates which is inhibited by N-acetyl-L-cysteine. Our studies suggest that the apoptotic process induced by curcumin is the mechanism mediating AK-5 tumor cell death. (C) 1999 Federation of European Biochemical Societies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 18:37:01