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Titolo:
The effects of iloprost infusion on microcirculation is independent of nitric oxide metabolites and endothelin-1 in chronic peripheral ischaemia
Autore:
Mazzone, A; Cusa, C; Bucci, L; Vezzoli, M; Ghio, S; Buggia, I; Regazzi, MB; Fossati, G; Mazzucchelli, I; Gritti, D;
Indirizzi:
Univvia,ia, Dept Internal Med & Nephrol, IRCCS, San Matteo Hosp, I-27100 Pa Univ Pavia Pavia Italy I-27100 phrol, IRCCS, San Matteo Hosp, I-27100 Pa Univ Pavia, Dept Pharmacol, IRCCS, San Matteo Hosp, I-27100 Pavia, Italy Univ Pavia Pavia Italy I-27100 CS, San Matteo Hosp, I-27100 Pavia, Italy
Titolo Testata:
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
fascicolo: 1, volume: 29, anno: 1999,
pagine: 1 - 5
SICI:
0014-2972(199901)29:1<1:TEOIIO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
INCREASED EXPRESSION; SYSTEMIC-SCLEROSIS; IN-VIVO; SCLERODERMA; ADHESION; ARTERIES; DISEASE; PHAGOCYTES; CELLS;
Keywords:
endothelin-1; iloprost; nitric oxide; peripheral artery occlusive disease; systemic sclerosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Mazzone, A Univ Pavia, Dept Internal Med & Nephrol, IRCCS, San Matteo Hosp, P Golgi 2, Univ Pavia P Golgi 2 Pavia Italy I-27100 tteo Hosp, P Golgi 2,
Citazione:
A. Mazzone et al., "The effects of iloprost infusion on microcirculation is independent of nitric oxide metabolites and endothelin-1 in chronic peripheral ischaemia", EUR J CL IN, 29(1), 1999, pp. 1-5

Abstract

Background Endothelial vascular tone modulators are thought to be involvedin aetiopathogenesis of systemic sclerosis (SS) and of peripheral artery occlusive disease (PAOD). Iloprost, a prostacyclin (PGI,) analogue, induces clinical benefit in patients suffering from peripheral ischaemia. This study was performed to investigate the effect of this drug on endothelial function in vivo to elucidate the role of vascular tone modulators. Methods Fourteen PAOD and 15 SS patients were treated for 24: and 10 days respectively On the first day, before and after therapy, nitric oxide metabolites (NO2-/NO3-) and endothelin-l (ET-1) plasma concentrations were detected; moreover, the endothelium-dependent vasodilatation in response to artificial ischaemia was evaluated by means of an echo-Doppler device. Results The echo-Doppler evaluation showed that the percentage of arterialreactive dilatation was not modified by placebo or by iloprost, and that the increase in blood velocity flow lasted for a significant longer time after drug infusion (226.79 +/- 17.49 vs. 310.71 +/- 36.32 s; P > 0 04). NO2-/NO3- and ET-1 plasma concentration were higher in patients than in control subjects (P < 0.004). After 6 h of iloprost infusion, no significant modifications were detected. Conclusion This study provides evidence that iloprost enhances the microvascular functional capacity and clinical benefit for patients. The effects of the drug seem to be independently or not directly correlated with its interactions with vascular tone modulators such as NO2-/NO3- or ET-1.

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Documento generato il 02/12/20 alle ore 06:57:47