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Titolo:
The effects of 8-OH-DPAT and (+/-)-pindolol on isolation-induced ultrasonic vocalizations in 3-, 10-, and 14-day-old rats
Autore:
Joyce, MP; Carden, SE;
Indirizzi:
Columbia10032 Coll Phys & Surg, Dept Psychiat Dev Psychobiol, New York, NYColumbia Univ Coll Phys & Surg New York NY USA 10032 hobiol, New York, NY
Titolo Testata:
DEVELOPMENTAL PSYCHOBIOLOGY
fascicolo: 2, volume: 34, anno: 1999,
pagine: 109 - 117
SICI:
0012-1630(199903)34:2<109:TEO8A(>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL RAPHE NEURONS; BLOOD-BRAIN-BARRIER; PUP ISOLATION CALLS; 5-HT1A RECEPTOR; POSTNATAL-DEVELOPMENT; ISOLATION DISTRESS; SEROTONERGIC MODULATION; 2-WEEK-OLD RATS; MESSENGER-RNA; AGONISTS;
Keywords:
rat; serotonin; 5-HT1A receptors; development; anxiety;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Joyce, MP NewUSArk State Psychiat Inst, Box 62,1051 Riverside Dr, New York, NY 10032 New York State Psychiat Inst Box 62,1051 Riverside Dr New York NY USA 10032
Citazione:
M.P. Joyce e S.E. Carden, "The effects of 8-OH-DPAT and (+/-)-pindolol on isolation-induced ultrasonic vocalizations in 3-, 10-, and 14-day-old rats", DEVELOP PSY, 34(2), 1999, pp. 109-117

Abstract

It has been established that administration of 5-HT1A agonists attenuates the I ate of isolation-induced ultrasonic vocalizations (USV) in IO-day-oldrat pups. In this study we extended these findings by examining the effects of administration of the serotonergic IA receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), and mixed 5-HT1A antagonist/beta adrenergic antagonist, (+/-)-pindolol, in 3-, 10-, and 14-day-old rat pups in order to assess the effect of these drugs fr om a developmental perspective. At all three ages, 8-OH-DPAT significantly reduced the rate of isolation-induced USV. While only the highest dose (1.0 mg/kg) of 8-OH-DPAT administered to the 10- and 14-day-olds significantly reduced the rate of vocalization, both the 0.1 - and 1.0-mg/kg doses significantly attenuated the vocalization rate in the 3-day-olds. Pindolol administration did not alter the rateof USV at any age nor did it block the quieting effect that generally occurs when an anesthetized littermate is placed with the isolated pup. We conclude that 8-OH-DPAT is effective as early as 3 days of age in the quieting of isolation-induced USV and that the regional age-dependent development of5-HT1A receptors and projections are important factors in the observed differential sensitivity to 8-OH-DPAT administration during development. (C) 1999 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:33:50