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Titolo:
Lymphomatosis cerebri presenting as a rapidly progressive dementia: Clinical, neuroimaging and pathologic findings
Autore:
Bakshi, R; Mazziotta, JC; Mischel, PS; Jahan, R; Seligson, DB; Vinters, HV;
Indirizzi:
Univ Calif Los Angeles, Sch Med, Dept Neurol, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univeles,f Los Angeles, Sch Med, Dept Pathol & Lab Med Neuropathol, Los Ang Univ Calif Los Angeles Los Angeles CA USA & Lab Med Neuropathol, Los Ang UnivCAalif Los Angeles, Sch Med, Dept Radiol Sci Neuroradiol, Los Angeles,Univ Calif Los Angeles Los Angeles CA USA Sci Neuroradiol, Los Angeles, Univ Calif Los Angeles, Med Ctr, Reed Neurol Res Ctr, Los Angeles, CA 90024 Univ Calif Los Angeles Los Angeles CA USA 90024 tr, Los Angeles, CA 90024 Univ Buffalo, Millard Fillmore Hosp, CGF, Dent Neurol Inst, Buffalo, NY USA Univ Buffalo Buffalo NY USA Hosp, CGF, Dent Neurol Inst, Buffalo, NY USA
Titolo Testata:
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
fascicolo: 2, volume: 10, anno: 1999,
pagine: 152 - 157
SICI:
1420-8008(199903/04)10:2<152:LCPAAR>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; MR; ENCEPHALITIS;
Keywords:
primary central nervous system lymphoma magnetic resonance imaging; lymphomatosis cerebri;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Bakshi, R Lucy Dent Imaging Ctr, 3 Gates Circle, Buffalo, NY 14209 USA Lucy Dent Imaging Ctr 3 Gates Circle Buffalo NY USA 14209 09 USA
Citazione:
R. Bakshi et al., "Lymphomatosis cerebri presenting as a rapidly progressive dementia: Clinical, neuroimaging and pathologic findings", DEMENT G C, 10(2), 1999, pp. 152-157

Abstract

Primary central nervous system lymphoma (PCNSL) usually presents with clinical and neuroimaging findings consistent with single or multiple intracranial mass lesions. On cranial magnetic resonance imaging (MRI), such lesionsare nearly always contrast enhancing, reflecting disruption of the blood-brain barrier at the site of tumor nodules, We describe 2 cases from the UCLA Medical Center who developed a rapidly progressive dementia due to extensive gray and white matter cerebral lesions involving much of the brain. In the patient who came to autopsy, widely infiltrating, focally necrotic B-cell plasmacytoid lymphoma was noted throughout the cerebral neuraxis, MRI findings in case 2 were consistent with diffuse lymphomatous brain infiltration without mass lesions, which was biopsy proven. We conclude that PCNSL may occur in a diffusely infiltrating form which may occur without MRI evidence of mass lesions or blood-brain barrier compromise, Vile refer to this entity as 'lymphomatosis cerebri' and add it to the differential diagnosis ofa rapidly progressive dementia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:43:50