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Titolo:
Evaluation of the thrombin inhibitor D-phenylalanyl-L-prolyl-L-arginine chloromethylketone (PPACK) with the factor Xa inhibitor 1,5-dansyl-L-glutamyl-L-glycyl-L-arginine chloromethylketone (GGACK) as anticoagulants for critical care clinical chemistry specimens
Autore:
Lyon, ME; Drobot, DW; Harding, SR; Lyon, AW;
Indirizzi:
Univ Saskatchewan, Coll Med, Dept Pharmacol, Saskatoon, SK S7N 0W0, CanadaUniv Saskatchewan Saskatoon SK Canada S7N 0W0 skatoon, SK S7N 0W0, Canada Univ Saskatchewan, Coll Med, Dept Pathol, Saskatoon, SK S7N 0W0, Canada Univ Saskatchewan Saskatoon SK Canada S7N 0W0 skatoon, SK S7N 0W0, Canada Saskatoon Dist Hlth, Dept Lab Med, Saskatoon, SK, Canada Saskatoon Dist Hlth Saskatoon SK Canada t Lab Med, Saskatoon, SK, Canada
Titolo Testata:
CLINICA CHIMICA ACTA
fascicolo: 1-2, volume: 280, anno: 1999,
pagine: 91 - 99
SICI:
0009-8981(199902)280:1-2<91:EOTTID>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNTHETIC THROMBIN; IONIZED MAGNESIUM; SERUM;
Keywords:
thrombin inhibitor; factor Xa inhibitor; anticoagulants; pre-analytical error; ionized calcium; electrolytes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Lyon, ME UnivS7Nskatchewan, Coll Med, Dept Pharmacol, 107 Wiggins Rd, Saskatoon, SK Univ Saskatchewan 107 Wiggins Rd Saskatoon SK Canada S7N 0W0 , SK
Citazione:
M.E. Lyon et al., "Evaluation of the thrombin inhibitor D-phenylalanyl-L-prolyl-L-arginine chloromethylketone (PPACK) with the factor Xa inhibitor 1,5-dansyl-L-glutamyl-L-glycyl-L-arginine chloromethylketone (GGACK) as anticoagulants for critical care clinical chemistry specimens", CLIN CHIM A, 280(1-2), 1999, pp. 91-99

Abstract

The objective of this study was to determine whether a thrombin inhibitor (PPACK) and a factor Xa inhibitor (GGACK) either alone or in combination can anticoagulate whole blood without biasing the analysis of several critical care analytes. Whole blood clot time was used to assess anticoagulant efficacy. The analytical biases mediated by the anticoagulants on glucose, urea, creatinine, electrolytes, amylase, lactate dehydrogenase, creatine kinase, ionized calcium and pH were assessed. The protease inhibitor mixture (100 mu mmol/l PPACK + 500 mu mol/l GGACK) was more a potent anticoagulant than the individual agents at the same concentrations. Both PPACK and GGACK, alone and in combination, reduced the activity of creatine kinase and amylase by 3-10% while the remaining critical care analytes were less affected. In conclusion, PPACK and GGACK mixtures can effectively anticoagulate whole blood, but the mixtures exert pre-analytical influences that limit the analytical versatility of these novel plasma-matrices. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 18:08:03