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Titolo:
Soluble interleukin 2 receptor levels and cervical neoplasia: Results froma population-based case-control study in Costa Rica
Autore:
Ung, A; Kramer, TR; Schiffman, M; Herrero, R; Bratti, MC; Burk, RD; Swanson, CA; Sherman, ME; Hutchinson, ML; Alfaro, M; Morales, J; Balmaceda, I; Hildesheim, A;
Indirizzi:
NCI,ryiv Canc Epidemiol & Genet, Environm Epidemiol Branch, Interdisciplina NCI Bethesda MD USA 20892 net, Environm Epidemiol Branch, Interdisciplina Howard Hughes Res Scholars Program, Bethesda, MD 20814 USA Howard Hughes Res Scholars Program Bethesda MD USA 20814 da, MD 20814 USA USDA,0705tsville Human Nutr Res Ctr, Carotenoids Res Unit, Beltsville, MD 2 USDA Beltsville MD USA 20705 Ctr, Carotenoids Res Unit, Beltsville, MD 2 WHO, Int Agcy Res Canc, Lyon 08, France WHO Lyon France 08WHO, Int Agcy Res Canc, Lyon 08, France Yeshiva Univ Albert Einstein Coll Med, Liver Res Ctr, Bronx, NY 10461 USA Yeshiva Univ Albert Einstein Coll Med Bronx NY USA 10461 nx, NY 10461 USA Johns Hopkins Univ Hosp, Dept Pathol, Baltimore, MD 21205 USA Johns Hopkins Univ Hosp Baltimore MD USA 21205 l, Baltimore, MD 21205 USA Tufts Univ, Sch Med, Dept Pathol, Boston, MA 02111 USA Tufts Univ Boston MA USA 02111 Sch Med, Dept Pathol, Boston, MA 02111 USA Caja Costaricense Seguro Social, San Jose, Costa Rica Caja Costaricense Seguro Social San Jose Costa Rica an Jose, Costa Rica
Titolo Testata:
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
fascicolo: 3, volume: 8, anno: 1999,
pagine: 249 - 253
SICI:
1055-9965(199903)8:3<249:SI2RLA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN PAPILLOMAVIRUS INFECTION; INTRAEPITHELIAL NEOPLASIA; ASSOCIATION; WOMEN; RESPONSES; BEHAVIOR; E7;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Hildesheim, A NCI,ryiv Canc Epidemiol & Genet, Environm Epidemiol Branch, Interdisciplina NCI EPN 443 Bethesda MD USA 20892 ol Branch, Interdisciplina
Citazione:
A. Ung et al., "Soluble interleukin 2 receptor levels and cervical neoplasia: Results froma population-based case-control study in Costa Rica", CANC EPID B, 8(3), 1999, pp. 249-253

Abstract

Progression from infection with human papillomavirus (HPV) to cervical cancer in some women is thought to involve a permissive host environment, one in which immune response is mobilized in an inappropriate manner, In a previous study (A, Hildesheim et al,, Cancer Epidemiol, Biomark, Prev,, 6: 807-813, 1997), increasing levels of soluble interleukin 2 receptor (sIL-2R), aknown proxy for general immune activation, was found to be positively associated with increasing levels of cervical neoplasia, We attempted to confirm this finding by conducting a nested case-control study of 478 women within a 10,000-woman population-based cohort in Costa Rica, We selected for thestudy all of the women diagnosed (at enrollment into the cohort) with: (a)low-grade squamous intraepithelial lesions (LSIL, n = 191); (b) high-gradesquamous intraepithelial lesions (HSIL, n = 130); or (c) cancer (n = 37), Controls were 120 cytologically normal, HPV-negative women selected from a random sample of the entire cohort. A questionnaire was administered to participants to elicit information on cervical cancer risk factors. All of thewomen received a pelvic examination during which cervical cells were collected and used for HPV DNA testing by PCR. Blood samples were also collected. Plasma obtained from the blood samples was tested for sIL-2R levels by ELISA. Results indicated that sIL-2R levels increased with age. Among controls, we observed that 44.3% of women over the age of 50 had high levels of sIL-2R (defined as >735 units/ml) compared with 15.8% of women <30 years of age (P = 0.008). When women with cervical disease (LSIL+) were compared withcontrols, women in the upper quartile of the sIL-2R distribution had an age-adjusted odds ratio (OR) of 2.1 [95% confidence interval (CI), 1.1-4.1]. Comparing each advancing state of neoplasia with its precursor, we found that women with LSIL had higher sIL-2R levels than controls (OR for upper quartile of sIL-2R, 2.3; 95% CI, 1.1-5.2; comparing LSIL cases with controls);women diagnosed with HSIL were similar to the LSIL group (OR for upper quartile of sIL-2R, 1.1; 95% CI, 0.5-2.4; comparing HSIL cases with LSIL cases); and those with cancer had higher sIL-2R levels than subjects with an HSIL diagnosis (OR for upper quartile of sIL-2R = 1.8; 95% CI, 0.5-7.1; comparing cancer cases with HSIL cases). These data suggest that among our study subjects, sIL-2R levels most likely rise as a response to the events of infection and cancerous invasion, but that sIL-2R levels are unlikely to be predictive of disease progression among women with LSIL.

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Documento generato il 27/01/21 alle ore 09:32:51