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Titolo: IMMUNOREACTION AT 43 KDA WITH ANTIUBIQUITIN ANTIBODY IN BREAST NEOPLASMS
Autore: IWAYA K; NISHIBORI H; OSADA T; MATSUNO Y; TSUDA H; SATO S; KONO H; FUKUTOMI T; SUZUKI M; TORIKATA C; IWAMATSU A; HIROHASHI S;
- Indirizzi:
- NATL CANC CTR,RES INST,DIV PATHOL,CHUO KU,5-1-1 TSUKIJI TOKYO 104 JAPAN NATL CANC CTR,RES INST,DIV PATHOL,CHUO KU TOKYO 104 JAPAN NATL CANC CTR,DEPT SURG,CHUO KU TOKYO 104 JAPAN NATL DEF MED COLL,DEPT PATHOL TOKOROZAWA SAITAMA 359 JAPAN KYOWA HAKKO KOGYO CO LTD SHIZUOKA 411 JAPAN KIRIN BREWERY CO LTD,CENT LABS KEY TECHNOL,KANAZAWA KU YOKOHAMA KANAGAWA 236 JAPAN
- Titolo Testata:
- Japanese journal of cancer research
fascicolo: 3,
volume: 88,
anno: 1997,
pagine: 273 - 280
- SICI:
- 0910-5050(1997)88:3<273:IA4KWA>2.0.ZU;2-A
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- SHORT-LIVED PROTEIN; HISTONE H2B; DEGRADATION; GENE; PATHWAY; SYSTEM; CELLS;
- Keywords:
- UBIQUITIN; ACTIN; BREAST NEOPLASM; 2-DIMENSIONAL ELECTROPHORESIS; AMINO ACID SEQUENCE;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Citazioni:
- 24
- Recensione:
- Indirizzi per estratti:
-
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- Citazione:
- K. Iwaya et al., "IMMUNOREACTION AT 43 KDA WITH ANTIUBIQUITIN ANTIBODY IN BREAST NEOPLASMS", Japanese journal of cancer research, 88(3), 1997, pp. 273-280
Abstract
Protein ubiquitination has been implicated in ATP-dependent protein turnover and normal cell proliferation. To investigate whether the ubiquitin-mediated system is functionally involved in the cancerous state,we examined changes in protein ubiquitination in 52 surgically resected primary breast tumors. Immunohistochemically, ubiquitin (Ub) was identified in the cytoplasm of cancer cells, which were stained more strongly than adjacent normal ductal epithelium. Corresponding immunoblotanalysis of normal and neoplastic regions of human breast showed thatthe immunoreaction for Ub at about 43 kDa was increased in all of thetumors (100%), regardless of the clinical stage or histologic grade. This protein, which gave a single spot on two-dimensional gel electrophoresis, had partial amino acid sequences which were identical to those of actin family members. Our results suggest that ubiquitination of this 43-kDa protein may be involved in the carcinogenesis or biological characteristics of human breast neoplasms.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 10:18:45