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Titolo:
Successful human umbilical cord blood stem cell transplantation without conditioning in severe combined immune deficiency
Autore:
Toren, A; Nagler, A; Amariglio, N; Neumann, Y; Golan, H; Bilori, B; Kaplinsky, C; Mandel, M; Biniaminov, M; Levanon, M; Rosenthal, E; Davidson, J; Brok-Simoni, F; Rechavi, G;
Indirizzi:
TelMediv Univ, Dept Pediat Hematooncol & BMT, Sackler Sch Med, Chaim ShebaTel Aviv Univ Tel Hashomer Israel IL-52621 Sackler Sch Med, Chaim Sheba Tel Aviv Univ, Inst Hematol, Sackler Sch Med, Chaim Sheba Med Ctr, IL-52621 Tel Aviv Univ Tel Hashomer Israel IL-52621 Chaim Sheba Med Ctr, IL-52621 Hadassahalem, Hosp, Israeli Human Umbilical Cord Blood Bank, IL-91120 Jerus Hadassah Univ Hosp Jerusalem Israel IL-91120 Blood Bank, IL-91120 Jerus Hebrew Univ Jerusalem, Jerusalem, Israel Hebrew Univ Jerusalem JerusalemIsrael niv Jerusalem, Jerusalem, Israel
Titolo Testata:
BONE MARROW TRANSPLANTATION
fascicolo: 4, volume: 23, anno: 1999,
pagine: 405 - 408
SICI:
0268-3369(199902)23:4<405:SHUCBS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE COMBINED IMMUNODEFICIENCY; HEMATOPOIETIC PROGENITOR CELLS; IN-UTERO TRANSPLANTATION; BONE-MARROW; UNRELATED DONORS; RECONSTITUTION; LYMPHOCYTES; ENGRAFTMENT; PATIENT; DISEASE;
Keywords:
severe combined immunodeficiency (SCID); human umbilical cord blood transplantation (HUCBT); microsatellite sequences; mixed chimerism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Toren, A TelMediv Univ, Dept Pediat Hematooncol & BMT, Sackler Sch Med, Chaim Sheba Tel Aviv Univ Tel Hashomer Israel IL-52621 Sch Med, Chaim Sheba
Citazione:
A. Toren et al., "Successful human umbilical cord blood stem cell transplantation without conditioning in severe combined immune deficiency", BONE MAR TR, 23(4), 1999, pp. 405-408

Abstract

A 2-month-old girl with severe combined immunodeficiency (SCID), presentedwith mild staphylococcal skin infection, lymphopenia, low T cell number, absence of B cells, high number of NK cells, and a negligible response to mitogens, Since her older brother died as a result of SCID 2 years earlier, cord blood was harvested from a sister born 2 1/2 years earlier, who was normal and fully matched both by serology and molecular typing. In view of herclinical condition and in spite of a high number of NK cells with normal activity, HUCBT without preparative conditioning was performed. No G-CSF wasadministered, Engraftment with mixed chimerism was evident 3 weeks post transplantation. There were no peritransplantation complications, Eighteen months post transplantation, the girl is in excellent condition, blood countsare normal, T cell engraftment is complete, B cell engraftment is proceeding gradually, and the mitogen stimulation tests are normal, Due to the unique nature of HUCB hematopoietic cells, engraftment without conditioning maybe possible in patients with SCID with fully matched donors. This is the first HUCBT performed without conditioning.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 18:29:19