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Titolo:
Identification of protein kinase B (PKB) as a phosphatidylinositol 3,4,5-trisphosphate binding protein in Dictyostelium discoideum
Autore:
Tanaka, K; Adachi, H; Konishi, H; Iwamatsu, A; Ohkawa, K; Shirai, T; Nagata, S; Kikkawa, U; Fukui, Y;
Indirizzi:
Univyookyo, Grad Sch Agr & Life Sci, Div Appl Biol Chem, Biol Chem Lab,Bunk Univ Tokyo Tokyo Japan 1130032 i, Div Appl Biol Chem, Biol Chem Lab,Bunk Univapanyo, Grad Sch Arts & Sci, Dept Life Sci, Meguro Ku, Tokyo 1538902, J Univ Tokyo Tokyo Japan 1538902 ept Life Sci, Meguro Ku, Tokyo 1538902, J Kobe Univ, Biosignal Res Ctr, Nada Ku, Kobe, Hyogo 6578501, Japan Kobe Univ Kobe Hyogo Japan 6578501 r, Nada Ku, Kobe, Hyogo 6578501, Japan Kirin Brewery Co Ltd, Cent Labs Key Technol, Kanazawa Ku, Kanagawa 2360004, Kirin Brewery Co Ltd Kanagawa Japan 2360004 nazawa Ku, Kanagawa 2360004,
Titolo Testata:
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
fascicolo: 2, volume: 63, anno: 1999,
pagine: 368 - 372
SICI:
0916-8451(199902)63:2<368:IOPKB(>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLECKSTRIN HOMOLOGY DOMAIN; 3-KINASE; ACTIVATION; GROWTH; PRODUCT; PATHWAY; CELLS; P110; AKT;
Keywords:
phosphatidylinositol 3,4,5-trisphosphate; PI-3 kinase; protein kinase B; Dictyostelium discoideum; phosphatidylinositol 3,4,5-trisphosphate binding protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Fukui, Y Univyookyo, Grad Sch Agr & Life Sci, Div Appl Biol Chem, Biol Chem Lab,Bunk Univ Tokyo 1-1-1 Yayoi Cho Tokyo Japan 1130032 iol Chem Lab,Bunk
Citazione:
K. Tanaka et al., "Identification of protein kinase B (PKB) as a phosphatidylinositol 3,4,5-trisphosphate binding protein in Dictyostelium discoideum", BIOS BIOT B, 63(2), 1999, pp. 368-372

Abstract

We have searched for phosphatidylinositol (PI)-3,4,5-trisphosphate (PIP3) binding proteins in Dictyostelium discoideum using beads bearing a PIP3 analogue, PIP3-APB. One of the binding proteins with a molecular mass of 55 kDa was purified and its amino acid sequence was partially amalyzed. Databasesearches showed that the analyzed sequence was identical to that of protein kinase B (PKB) of D. discoideum. The specific activity of D. discoideum PKB, when expressed together with constitutively active PI-3 kinase in mammalian cells, was elevated by about three-fold, suggesting that PKB could also act downstream of PI-3 kinase in Dictyostelium cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 03:49:28