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Titolo:
Prostanoids for chronic critical leg ischemia - A randomized, controlled, open-label trial with prostaglandin E-1
Autore:
Belgrano, EA; Guala, A; Mazzucchetti, S; Marinoni, V; Calzoni, D; Bedoni, P; Confalonieri, MA; Agus, GB; Mondani, P; De Angelis, R; Biasi, GM; Piglionica, MR; Abbritti, F; Agrifoglio, G; Costantini, A; Della Vedova, MR; Miglierina, L; Marrocu, R; Bragherio, G; Zanoni, CE; Borin, F; Alderi, G; Emanuelli, G; Colzani, M; Ponti, GB; Berra, S; Bevilacqua, A; Bocca, M; Invernizzi, C; De Angelis, E; Tacconi, A; DAngelo, F; Vaghi, M; Arzini, A; Boccalon, L; Losapio, GM; Ambrosi, R; Briolini, F; Inzoli, MR; Lombardi, G; Tarantola, P; Zocca, N; Tenchini, P; Fontanili, M; Guidetti, D; Pedeferri, G; Bordoni, MC; Catalano, A; Visconti, W; Vedovato, F; Zucchella, M; Bon, GB; Busetto, MT; Zambon, C; Carlassara, GB; Zambelli, V; Barbato, O; Mazzilli, G; Lino, M; Pavan, S; Pagnan, A; Visona, A; Perissinotto, C; Tonietto, G; Michelet, I; Agresta, F; Favretti, F; Burigo, E; De Lazzer, L; Giansante, C; Fiotti, N; Grego, S; Mozzon, L; Gonano, N; Pfeiffer, P; Petrilli, GL; Puzzo, A; Baldino, G; Podesta, A; Guastini, A; Traversaro, A; Zinicola, N; Baglietto, F; Arnuzzo, L; De Fabritiis, A; Filippini, M; Ferrari, F; Martini, L; Testoni, P; Accorsi, F; Maurizi, P; Evangelisti, G; Roffi, A; Marzara, G; Fini, C; Coppi, G; Camparini, S; Tusini, N; Tuscano, G; Lonardi, R; Rozza, A; Botta, GC; Villani, LG; Pavarini, E; Campanella, P; Moratti, A; Ieran, M; Bertini, D; Pratesi, C; Narcetti, S; Corsi, C; Pollastri, M; Marrapodi, E; Melillo, E; Iabichella, ML; Setacci, C; Sozio, G; Cao, P; Verzini, F; Mannarino, E; Pasqualini, L; Vaudo, G; Alo, F; Ioannidis, G; Spartera, C; Marino, G; Bafile, G; Anselmi, E; Maniscalco, G; Longo, P; Di Giovanni, V; Colli, R; Bracale, G; Bernardo, B; Perretti, B; Valitutti, P; Vigliotti, G; Rolli, F; Pascali, M; Sabella, G; Grilli, M; Correra, M; Palese, E; Florena, M; Cassina, I; Cumbo, P; Comande, C; Notarbartolo, A; Novo, S; Belvedere, M; Caruso, R; Verghi, F; Romeo, S; Cormaci, OF; Binaghi, F; Fronteddu, P; Cannas, F; de Gaetano, G; Tognoni, G; Avanzini, F; Bertele, V; Di Giulio, P; Pangrazzi, J; Roncaglioni, MC; Colombo, F; Terzian, E; Coccheri, S; Del Favero, A; Geraci, E; Janzon, L; Vermylen, J; Baldino, G; Beghi, E; Coen, D; Nardella, L; Turazza, F;
Indirizzi:
Infermi Hosp, Biella, Italy Infermi Hosp Biella ItalyInfermi Hosp, Biella, Italy S Carlo Borromeo Hosp, Milan, Italy S Carlo Borromeo Hosp Milan ItalyS Carlo Borromeo Hosp, Milan, Italy Santa Rita Clin, Milan, Italy Santa Rita Clin Milan ItalySanta Rita Clin, Milan, Italy Bassini Hosp, Balsamo, Italy Bassini Hosp Balsamo ItalyBassini Hosp, Balsamo, Italy Inst Clin Perfezionamento, Milan, Italy Inst Clin Perfezionamento Milan Italy lin Perfezionamento, Milan, Italy G Fornaroli Hosp, Magenta, Italy G Fornaroli Hosp Magenta ItalyG Fornaroli Hosp, Magenta, Italy S Gerardo dei Tintori Hosp, Monza, Italy S Gerardo dei Tintori Hosp Monza Italy o dei Tintori Hosp, Monza, Italy Rho Hosp, Rho, Italy Rho Hosp Rho ItalyRho Hosp, Rho, Italy Predabissi Hosp, Vizzolo Predabissi, Italy Predabissi Hosp Vizzolo Predabissi Italy osp, Vizzolo Predabissi, Italy Santa Corona Hosp, Garbagnate Milanese, Italy Santa Corona Hosp Garbagnate Milanese Italy Garbagnate Milanese, Italy Osped Riuniti Bergamo, I-24100 Bergamo, Italy Osped Riuniti Bergamo Bergamo Italy I-24100 gamo, I-24100 Bergamo, Italy S Orsola Hosp, Brescia, Italy S Orsola Hosp Brescia ItalyS Orsola Hosp, Brescia, Italy Carlo Poma Hosp, Mantova, Italy Carlo Poma Hosp Mantova ItalyCarlo Poma Hosp, Mantova, Italy Bormio & Sondalo Hosp, Sondalo, Italy Bormio & Sondalo Hosp Sondalo Italy rmio & Sondalo Hosp, Sondalo, Italy Al Mare Hosp, Venice, Italy Al Mare Hosp Venice ItalyAl Mare Hosp, Venice, Italy Civile Hosp, Venice, Italy Civile Hosp Venice ItalyCivile Hosp, Venice, Italy Mirano Hosp, Mirano, Italy Mirano Hosp Mirano ItalyMirano Hosp, Mirano, Italy Policlin Borgo Hosp, Verona, Italy Policlin Borgo Hosp Verona ItalyPoliclin Borgo Hosp, Verona, Italy Castelfranco Hosp, Castelfranco Veneto, Italy Castelfranco Hosp Castelfranco Veneto Italy Castelfranco Veneto, Italy Civile Hosp, Vittorio Veneto, Italy Civile Hosp Vittorio Veneto ItalyCivile Hosp, Vittorio Veneto, Italy Presidio Hosp, Belluno, Italy Presidio Hosp Belluno ItalyPresidio Hosp, Belluno, Italy Univ Trieste, Trieste, Italy Univ Trieste Trieste ItalyUniv Trieste, Trieste, Italy S Maria Misericordia Hosp, Udine, Italy S Maria Misericordia Hosp Udine Italy a Misericordia Hosp, Udine, Italy Galliera Hosp, Genoa, Italy Galliera Hosp Genoa ItalyGalliera Hosp, Genoa, Italy Lavagna Hosp, Lavagna, Italy Lavagna Hosp Lavagna ItalyLavagna Hosp, Lavagna, Italy Santa Corona Hosp, Pietra Ligure, Italy Santa Corona Hosp Pietra Ligure Italy Corona Hosp, Pietra Ligure, Italy S Orsola M Malpighi Hosp, Bologna, Italy S Orsola M Malpighi Hosp Bologna Italy M Malpighi Hosp, Bologna, Italy Maggiore Hosp, Bologna, Italy Maggiore Hosp Bologna ItalyMaggiore Hosp, Bologna, Italy Civile Nuovo Hosp, Imola, Italy Civile Nuovo Hosp Imola ItalyCivile Nuovo Hosp, Imola, Italy S Agostino Hosp, Modena, Italy S Agostino Hosp Modena ItalyS Agostino Hosp, Modena, Italy Policlinico, Modena, Italy Policlinico Modena ItalyPoliclinico, Modena, Italy Maggiore Hosp, Parma, Italy Maggiore Hosp Parma ItalyMaggiore Hosp, Parma, Italy S Maria Nuova Hosp, Reggio Emilia, Italy S Maria Nuova Hosp Reggio Emilia Italy Nuova Hosp, Reggio Emilia, Italy Careggi Hosp, Florence, Italy Careggi Hosp Florence ItalyCareggi Hosp, Florence, Italy Santa Chiara Clin, Florence, Italy Santa Chiara Clin Florence ItalySanta Chiara Clin, Florence, Italy Cisanello Hosp, Pisa, Italy Cisanello Hosp Pisa ItalyCisanello Hosp, Pisa, Italy Le Scotte Hosp, Siena, Italy Le Scotte Hosp Siena ItalyLe Scotte Hosp, Siena, Italy Monteluce Hosp, Perugia, Italy Monteluce Hosp Perugia ItalyMonteluce Hosp, Perugia, Italy Torrette Hosp, Ancona, Italy Torrette Hosp Ancona ItalyTorrette Hosp, Ancona, Italy San Salvatore Hosp, Laquila, Italy San Salvatore Hosp Laquila ItalySan Salvatore Hosp, Laquila, Italy Filippo Neri Hosp, Rome, Italy Filippo Neri Hosp Rome ItalyFilippo Neri Hosp, Rome, Italy A Gemelli Hosp, Rome, Italy A Gemelli Hosp Rome ItalyA Gemelli Hosp, Rome, Italy 2 Policlin, Naples, Italy 2 Policlin Naples Italy2 Policlin, Naples, Italy San Giovanni di Dio & Ruggi dAragona Hosp, Salerno, Italy San Giovanni di Dio & Ruggi dAragona Hosp Salerno Italy Salerno, Italy A Di Summa Hosp, Brindisi, Italy A Di Summa Hosp Brindisi ItalyA Di Summa Hosp, Brindisi, Italy Sollievo Sofferenza Clin, San Giovanni Rotondo, Italy Sollievo Sofferenza Clin San Giovanni Rotondo Italy anni Rotondo, Italy F Ferrari Hosp, Casarano, Italy F Ferrari Hosp Casarano ItalyF Ferrari Hosp, Casarano, Italy Paolo Giaccone Hosp, Palermo, Italy Paolo Giaccone Hosp Palermo ItalyPaolo Giaccone Hosp, Palermo, Italy Garibaldi Hosp, Catania, Italy Garibaldi Hosp Catania ItalyGaribaldi Hosp, Catania, Italy Policlinico, Cagliari, Italy Policlinico Cagliari ItalyPoliclinico, Cagliari, Italy Univ Milan, Milan, Italy Univ Milan Milan ItalyUniv Milan, Milan, Italy IstaRic Farmacol Mario Negri, Consorzio Mario Negri Sud, I-66030 Santa Mari Ist Ric Farmacol Mario Negri Santa Maria Imbaro Italy I-66030 Santa Mari Magio Negri Inst, Milan, Italy Magio Negri Inst Milan ItalyMagio Negri Inst, Milan, Italy Univ Bologna, Bologna, Italy Univ Bologna Bologna ItalyUniv Bologna, Bologna, Italy Univ Perugia, I-06100 Perugia, Italy Univ Perugia Perugia Italy I-06100Univ Perugia, I-06100 Perugia, Italy Cervello Hosp, Palermo, Italy Cervello Hosp Palermo ItalyCervello Hosp, Palermo, Italy Univ Lund, Lund, Sweden Univ Lund Lund SwedenUniv Lund, Lund, Sweden Katholieke Univ Leuven, Louvain, Belgium Katholieke Univ Leuven Louvain Belgium ke Univ Leuven, Louvain, Belgium S Gerardo Hosp, Monza, Italy S Gerardo Hosp Monza ItalyS Gerardo Hosp, Monza, Italy Fatebenefratelli Hosp, Milan, Italy Fatebenefratelli Hosp Milan ItalyFatebenefratelli Hosp, Milan, Italy Mario Negri Inst Pharmacol Res, I-20157 Milan, Italy Mario Negri Inst Pharmacol Res Milan Italy I-20157 I-20157 Milan, Italy Santa Croce Hosp, Cuneo, Italy Santa Croce Hosp Cuneo ItalySanta Croce Hosp, Cuneo, Italy S Agostino Hosp, Modena, Italy S Agostino Hosp Modena ItalyS Agostino Hosp, Modena, Italy Monteluce Hosp, Perugia, Italy Monteluce Hosp Perugia ItalyMonteluce Hosp, Perugia, Italy
Titolo Testata:
ANNALS OF INTERNAL MEDICINE
fascicolo: 5, volume: 130, anno: 1999,
pagine: 412 -
SICI:
0003-4819(19990302)130:5<412:PFCCLI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTICENTER TRIAL; ARTERIAL-DISEASE; LIMB ISCHEMIA; ILOPROST; PROSTACYCLIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Bertele, V Mario Negri Inst Pharmacol Res, Via Eritrea 62, I-20157 Milan, Italy Mario Negri Inst Pharmacol Res Via Eritrea 62 Milan Italy I-20157
Citazione:
E.A. Belgrano et al., "Prostanoids for chronic critical leg ischemia - A randomized, controlled, open-label trial with prostaglandin E-1", ANN INT MED, 130(5), 1999, pp. 412

Abstract

Background: No effective pharmacologic intervention is available for critical leg ischemia, a severe clinical condition associated with high morbidity and mortality. Objective: To assess the safety and efficacy of prostaglandin E-1 in improving the prognosis and quality of life in patients with critical leg ischemia. Design: Multicenter, centrally randomized, controlled, open-label trial. Setting: 56 vascular surgery and angiology departments of the Italian National Health Service. Patients: 1560 patients with chronic critical leg ischemia. Interventions: In addition to routine treatments practiced in each center,patients were randomly assigned to receive either a daily intravenous infusion of 60 mu g of prostaglandin E-1 in the form of alprostadil-alpha-cyclodextrine (n = 771) or no prostaglandin E-1 (n = 789) during their hospital stay. The treatment period lasted for up to 28 days. Measurements: A combined end point consisting of death and peripheral and cardiocerebrovascular illness (major amputation or persistence of critical leg ischemia, acute myocardial infarction, or stroke) evaluated at hospitaldischarge and during 6 months of follow-up. Results: The incidence of the combined outcome measure was lower in the alprostadil group than in controls at hospital discharge (493 [63.9%] patients compared with 581 [73.6%] patients; relative risk, 0.87 [95% CI, 0.81 to 0.93]; P < 0.001) but differed only modestly at 6 months (348 of 661 [52.6%] patients compared with 387 of 673 [57.5%] patients; relative risk, 0.92 [CI, 0.83 to 1.01]; P = 0.074). Most of the observed benefit was due to recovery from critical leg ischemia. Conclusions: Short-term treatment with alprostadil-alpha-cyclodextrine provides patients with critical leg ischemia clinical benefit that is apparentin the short term but decreases over time.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 19:56:56