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Titolo:
Comparison of European and North American malignant hyperthermia diagnostic protocol outcomes for use in genetic studies
Autore:
Fletcher, JE; Rosenberg, H; Aggarwal, M;
Indirizzi:
Hahnemann Univ Hosp, Dept Anesthesiol, Philadelphia, PA 19102 USA Hahnemann Univ Hosp Philadelphia PA USA 19102 Philadelphia, PA 19102 USA Thomas Jefferson Univ, Dept Anesthesiol, Philadelphia, PA 19107 USA ThomasJefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA
Titolo Testata:
ANESTHESIOLOGY
fascicolo: 3, volume: 90, anno: 1999,
pagine: 654 - 661
SICI:
0003-3022(199903)90:3<654:COEANA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCLE CONTRACTURE TEST; SKELETAL-MUSCLE; RYR1 GENE; HALOTHANE; SUSCEPTIBILITY; PEDIGREE; SUBSTITUTION; DISCORDANCE; MUTATION; RECEPTOR;
Keywords:
anesthetic complications; muscle rigidity; succinylcholine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Fletcher, JE TrinityPAommun, 4 Tower Bridge,200 Barr Harbor Dr,Suite 222, Conshohocken, Trinity Commun 4 Tower Bridge,200 Barr Harbor Dr,Suite 222 Conshohocken PA USA 19428
Citazione:
J.E. Fletcher et al., "Comparison of European and North American malignant hyperthermia diagnostic protocol outcomes for use in genetic studies", ANESTHESIOL, 90(3), 1999, pp. 654-661

Abstract

Background: Halothane and caffeine diagnostic protocols and an experimental ryanodine test from the North American Malignant Hyperthermia (MH) Group (NAMHG) and the European MII Group (FMHG) have not been compared in the same persons until now. Methods: The outcomes of the NAMHG and EMHG halothane and caffeine contracture tests were compared in 84 persons referred for diagnostic testing. In addition, the authors assessed the experimental ryanodine protocol in 50 ofthese persons. Results: Although the NAMHG and EMHG halothane protocols are slightly different methodologically, each yielded outcomes in close (84-100%) agreement with diagnoses made by the other protocol. Excluding 23 persons judged to be equivocal (marginally positive responders) by the EMHG protocol resulted in fewer persons classified as normal and MH susceptible (42 and 19, respectively) than those classified by the NAMHG protocol (48 and 34, respectively). For the G1 persons not excluded as equivocal, the diagnoses were identical by both protocols, with the exception of one person who was diagnosed as MII susceptible by the NAMHG protocol and as "normal" by the EMHG protocol. The NAMHG protocol produced only mo equivocal diagnoses. Therefore, a normal or MH diagnosis by the NAMHG protocol was frequently associated with an equivocal diagnosis by the EMHG protocol. The time to 0.2-g contracture after the addition of 1 mu M ryanodine completely separated populations, which was in agreement with the EMHG protocol and, except for one person, withthe NAMHG protocol. Conclusions: Overall, the NAMHG and EMHG protocols and the experimental ryanodine test yielded similar diagnoses. The EMI-IG protocol reduced the number of marginal responders in the final analysis, which may make the remaining diagnoses slightly more accurate for use in genetic studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:23:55