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Titolo:
Electrospray ionization mass spectrometry of tetracycline, oxytetracycline, chlorotetracycline, minocycline, and methacycline
Autore:
Kamel, AM; Brown, PR; Munson, B;
Indirizzi:
Pfizer Inc, Div Cent Res, Dept Drug Metab, Groton, CT 06340 USA Pfizer Inc Groton CT USA 06340 Res, Dept Drug Metab, Groton, CT 06340 USA Univ Rhode Isl, Dept Chem, Kingston, RI 02881 USA Univ Rhode Isl KingstonRI USA 02881 l, Dept Chem, Kingston, RI 02881 USA Univ Delaware, Dept Chem & Biochem, Newark, DE 19716 USA Univ Delaware Newark DE USA 19716 pt Chem & Biochem, Newark, DE 19716 USA
Titolo Testata:
ANALYTICAL CHEMISTRY
fascicolo: 5, volume: 71, anno: 1999,
pagine: 968 - 977
SICI:
0003-2700(19990301)71:5<968:EIMSOT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; NEGATIVE-ION FORMATION; VOLATILE MOBILE-PHASE; RESIDUAL TETRACYCLINES; ATMOSPHERIC-PRESSURE; CHEMICAL-ANALYSIS; CYTOKININ METABOLISM; TRANSGENIC TOBACCO; BOVINE-TISSUES; ANIMAL-TISSUES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Kamel, AM Pfizer Inc, Div Cent Res, Dept Drug Metab, Groton, CT 06340 USA Pfizer Inc Groton CT USA 06340 Drug Metab, Groton, CT 06340 USA
Citazione:
A.M. Kamel et al., "Electrospray ionization mass spectrometry of tetracycline, oxytetracycline, chlorotetracycline, minocycline, and methacycline", ANALYT CHEM, 71(5), 1999, pp. 968-977

Abstract

The effects of mobile-phase additives and analyte concentration on electrospray ionization mass spectra of a series of tetracyclines were investigated in both positive and negative ion modes. Only [M + H](+) and [M - H](-) ions were observed. The greatest sensitivity as [M + H](+) ions was obtainedwith 1% acetic acid and the greatest sensitivity as [M - H](-) ions was obtained using 50 mM. ammonium hydroxide. Sensitivities in the positive ion mode were greater than those in the negative ion mode. The sensitivity as [M+ H](+) showed no systematic variation with pH; however, the sensitivity as [M - H](-) did increase with increasing pH. A larger linear range was observed for [M - H](-) than for [M + H](+) ions. Both [M + Na](+) and [IM + H](+) ions were observed with 0.5 mM sodium acetate and sodium iodide, but no adduct ions were observed with ammonium acetate. Some M2H+ ions were observed at higher concentrations. Cluster ions, Na(NaOAc)(n)(+) or Na(NaI)(n)(), but no sample ions were observed using 5 mM salts. The data suggest that mechanisms in addition to solution ionization are involved in the formation of the ESI sample ions. The utility of mobile phases containing 1% HOAc or 50 mM NH4OH was demonstrated for chromatographic separations.

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Documento generato il 30/03/20 alle ore 19:38:02