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Titolo:
Acute Chagas' disease in western Venezuela: A clinical, seroparasitologic,and epidemiologic study
Autore:
Anez, N; Carrasco, H; Parada, H; Crisante, G; Rojas, A; Gonzalez, N; Ramirez, JL; Guevara, P; Rivero, C; Borges, R; Scorza, JV;
Indirizzi:
Univlaos Andes, Fac Ciencias, Dept Biol, Inst Cardiol, Merida 5101, Venezue Univ Los Andes Merida Venezuela 5101 Inst Cardiol, Merida 5101, Venezue Univ Los Andes, Inst Estadist Aplicada, Merida 5101, Venezuela Univ Los Andes Merida Venezuela 5101 st Aplicada, Merida 5101, Venezuela Cent Univ Venezuela, Fac Ciencias, Caracas, Venezuela Cent Univ VenezuelaCaracas Venezuela Fac Ciencias, Caracas, Venezuela Hosp Luis Razetti, Unidad Cardiol, Barinas, Venezuela Hosp Luis Razetti Barinas Venezuela Unidad Cardiol, Barinas, Venezuela
Titolo Testata:
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
fascicolo: 2, volume: 60, anno: 1999,
pagine: 215 - 222
SICI:
0002-9637(199902)60:2<215:ACDIWV>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRYPANOSOMA-CRUZI; STOCKS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Anez, N Univlaos Andes, Fac Ciencias, Dept Biol, Inst Cardiol, Merida 5101, Venezue Univ Los Andes Merida Venezuela 5101 rdiol, Merida 5101, Venezue
Citazione:
N. Anez et al., "Acute Chagas' disease in western Venezuela: A clinical, seroparasitologic,and epidemiologic study", AM J TROP M, 60(2), 1999, pp. 215-222

Abstract

A clinical, parasitologic, and serologic study carried out between 1988 and 1996 on 59 acute-phase patients in areas of western Venezuela where Chagas' disease is endemic showed 19 symptomatic patterns or groups of symptoms appearing in combination with different frequencies. The symptomatic pattern with the highest frequency was that showing simultaneously fever, myalgia, headache, and Romana's sign, which was detected in 20% of the acute-phasepatients. Asymptomatic individuals and patients with fever as the only sign of the disease made up 15% and 11.9% of the total acute cases, respectively. Statistical correlation analysis revealed that xenodiagnosis and hemoculture were the most reliable and concordant of the five parasitologic methods used; these two methods also showed the highest proportions in detectingany clinical symptomatic pattern in acute-phase patients. A similar high reliability and concordance was obtained with a direct agglutination test, an indirect immunofluorescent antibody test, and an ELISA as serologic tests, which also showed a higher proportion of positive detection of clinical patterns than parasitologic methods (P < 0.001). It is recommended that individuals coming from endemic areas showing mild and/or severe clinical manifestations should be suspected of being in contact or having been in contactwith Trypanosoma cruzi, be referred for parasitologic and serologic evaluations to confirm the presumptive clinical diagnosis of acute Chagas' disease, and start specific treatment. The epidemiologic implications of the present findings are discussed and the use of similar methodology to evaluate other areas where Chagas' disease is endemic is suggested.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 16:55:31