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Titolo:
Long-term maintenance of weight loss after a very-low-calorie diet: A randomized blinded trial of the efficacy and tolerability of sibutramine
Autore:
Apfelbaum, M; Vague, P; Ziegler, O; Hanotin, C; Thomas, F; Leutenegger, E;
Indirizzi:
Labs Knoll France, Dept Med, F-92593 Levallois, France Labs Knoll France Levallois France F-92593 ed, F-92593 Levallois, France Bichat Hosp, Dept Nutr, Paris, France Bichat Hosp Paris FranceBichat Hosp, Dept Nutr, Paris, France La Timone Hosp, Dept Endocrinol, Marseille, France La Timone Hosp Marseille France osp, Dept Endocrinol, Marseille, France Jeanne dArc Hosp, Serv Diabetol Malad Metab & Nutr, Toul, France Jeanne dArc Hosp Toul France Diabetol Malad Metab & Nutr, Toul, France
Titolo Testata:
AMERICAN JOURNAL OF MEDICINE
fascicolo: 2, volume: 106, anno: 1999,
pagine: 179 - 184
SICI:
0002-9343(199902)106:2<179:LMOWLA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-DISEASE; FOLLOW-UP; OBESITY; DEXFENFLURAMINE; BEHAVIOR; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Thomas, F Labsancell France, Dept Med, 49 Ave Georges Pompidou, F-92593 Levallois, Fr Labs Knoll France 49 Ave Georges Pompidou Levallois France F-92593
Citazione:
M. Apfelbaum et al., "Long-term maintenance of weight loss after a very-low-calorie diet: A randomized blinded trial of the efficacy and tolerability of sibutramine", AM J MED, 106(2), 1999, pp. 179-184

Abstract

BACKGROUND: Very-low-calorie diets are a well established method to achieve substantial short-term weight loss in obese patients, but long-term maintenance of the weight loss is very disappointing. A combined very-low-calorie diet and pharmacologic approach could be an effective means of prolongingits benefits. PATIENTS AND METHODS: Eligible patients had a body-mass index greater than30 kg/m(2); those who lost 6 kg or more during a 4-week treatment with a very-low-calorie diet were randomly assigned to 1 year of treatment with sibutramine (10 mg) or identical placebo. RESULTS: In an intention-to-treat analysis, mean (+/- SD) absolute weight change at 1 year (or study endpoint) was -5.2 (+/- 7.5) kg in the 81 patients in the sibutramine group and +/- 0.5 (15.7) kg in the 78 patients in theplacebo group (P = 0.004). When compared with their weight at study entry (before the very-low-calorie diet), 86% of patients in the sibutramine group had lost at least 5% of their weight, compared with only 55% of those in the placebo group (P < 0.001) at the study endpoint. Similarly, at month 12, 75% of subjects in the sibutramine group maintained at least 100% of the weight loss achieved with a very-low-calorie diet, compared with 42% in theplacebo group (P < 0.01). CONCLUSION: Following a very-low-calorie diet, sibutramine is effective inmaintaining and improving weight loss for up to 1 year. Am J Med, 1999;106:179-184. (C) 1999 by Excerpta Medica, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 18:54:44