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Titolo:
The noninvasive prediction of cardiac mortality in men and women with known or suspected coronary artery disease
Autore:
Marwick, TH; Shaw, LJ; Lauer, MS; Kesler, M; Hachamovitch, R; Heller, GV; Travin, MI; Borges-Neto, S; Berman, DS; Miller, DD;
Indirizzi:
Cleveland Clin Fdn, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 in Fdn, Cleveland, OH 44195 USA Duke Univ, Med Ctr, Durham, NC USA Duke Univ Durham NC USADuke Univ, Med Ctr, Durham, NC USA Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA Cedars Sinai Med Ctr Los Angeles CA USA 90048 , Los Angeles, CA 90048 USA Hartford Hosp, Hartford, CT 06115 USA Hartford Hosp Hartford CT USA 06115Hartford Hosp, Hartford, CT 06115 USA Roger Williams Univ, Providence, RI USA Roger Williams Univ Providence RIUSA Williams Univ, Providence, RI USA St Louis Univ, Med Ctr, St Louis, MO USA St Louis Univ St Louis MO USASt Louis Univ, Med Ctr, St Louis, MO USA
Titolo Testata:
AMERICAN JOURNAL OF MEDICINE
fascicolo: 2, volume: 106, anno: 1999,
pagine: 172 - 178
SICI:
0002-9343(199902)106:2<172:TNPOCM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMISSION COMPUTED-TOMOGRAPHY; INCREMENTAL PROGNOSTIC VALUE; MYOCARDIAL PERFUSION SPECT; ISCHEMIC-HEART-DISEASE; EXERCISE ELECTROCARDIOGRAPHY; TC-99M SESTAMIBI; RISK STRATIFICATION; ECHOCARDIOGRAPHY; SCINTIGRAPHY; PROBABILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Marwick, TH Univtraliasland, Princess Alexandra Hosp, Dept Med, Brisbane, Qld 4102, Aus Univ Queensland Brisbane Qld Australia 4102 ne, Qld 4102, Aus
Citazione:
T.H. Marwick et al., "The noninvasive prediction of cardiac mortality in men and women with known or suspected coronary artery disease", AM J MED, 106(2), 1999, pp. 172-178

Abstract

PURPOSE: The association between myocardial perfusion imaging defects and cardiac mortality in women is undefined. We examined whether myocardial perfusion imaging predicted cardiac mortality in men and women and compared this with other variables influencing prognosis. SUBJECTS AND METHODS: Six academic institutions with high-volume nuclear cardiology laboratories consecutively studied 5,009 men aged 62 +/- 12 years(mean ISD) and 3,402 women aged 66 +/- 11 years with symptomatic known or suspected coronary artery disease undergoing exercise (n = 7,486) or pharmacologic stress (n = 925) myocardial perfusion imaging. A pretest clinical risk index was calculated from age, history of myocardial infarction, diabetes, hypertension, and hypercholesterolemia. Myocardial perfusion images were analyzed for stress-induced defects or any defect in the territories of the three major coronary arteries. RESULTS: Stress-induced perfusion defects were seen in 39% of men and 25% of women (P = 0.0001). Extensive stress-induced or fixed defects (>2 vascular territories) were less common in women than men (10% vs 19%, and 4% vs 18%, both P = 0.0001). During a mean of 2.4 +/- 1.5 years of follow-up, 143 patients died of cardiac causes. The clinical risk index and number of territories with perfusion defects were associated with cardiac mortality in women and men. In women undergoing exercise myocardial perfusion imaging, thenumber of abnormal territories remained the strongest correlate of mortality after adjustment for exercise variables. CONCLUSIONS: The results of myocardial perfusion imaging are important, independent predictors of survival in both women and men. Am J Med. 1999;106:172-178. (C) 1999 by Excerpta Medica, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:01:18