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Titolo:
Standard gentamicin dosage regimen in neonates
Autore:
Langlass, TM; Mickle, TR;
Indirizzi:
McAllen Med Ctr, Dept Pharm, Owen Healthcare Inc, Mcallen, TX 78503 USA McAllen Med Ctr Mcallen TX USA 78503 ealthcare Inc, Mcallen, TX 78503 USA
Titolo Testata:
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
fascicolo: 5, volume: 56, anno: 1999,
pagine: 440 - 443
SICI:
1079-2082(19990301)56:5<440:SGDRIN>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINOGLYCOSIDE; EFFICACY;
Keywords:
aminoglycosides; dosage; dosage schedules; gentamicin sulfate; pediatrics; pharmacokinetics; protocols;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Langlass, TM McAllenlen, Ctr, Dept Pharm, Owen Healthcare Inc, 301 W Expressway 83, Mcal McAllen Med Ctr 301 W Expressway 83 Mcallen TX USA 78503 Mcal
Citazione:
T.M. Langlass e T.R. Mickle, "Standard gentamicin dosage regimen in neonates", AM J HEAL S, 56(5), 1999, pp. 440-443

Abstract

A standard gentamicin dosage regimen intended to result in fewer trough concentrations of >2 mu g/mL was studied. At a neonatal intensive care unit, gentamicin dosage guidelines of 2.5 mg/kg (as the sulfate) administered i.v. over 30 minutes every 12, 18, or 24 hours to neonates with a gestational age (GA) of greater than or equal to 30weeks were resulting in some relatively high trough serum concentrations (>2 mu g/mL). Pharmacokinetic values derived for this baseline group were used to predict the gentamicin concentrations that would result from a standard regimen of gentamicin 3.5 mg/kg i.v, over 30 minutes every 24 hours. No patient in the baseline group was predicted to have a trough of >2 mu g/mL with the new regimen, which was then approved for routine use. The new regimen was used for every neonate with a GA of greater than or equal to 30 weeks who was admitted and treated with gentamicin (the protocol group). One set of concentrations was collected for each infant. Compared with the baseline group, the protocol group had significantly lower trough and significantly higher peak gentamicin concentrations. The fetal frequency of high troughs in the baseline group (23 [33%] of 69 patients)differed significantly from that in the protocol group (3 [4%] of 74 patients). No patient had or developed renal impairment,A gentamicin dosage protocol of 3.5 mg/kg every 24 hours for neonates witha GA of WO weeks resulted in higher gentamicin peaks, lower troughs, and alower frequency Of troughs of >2 mu g/mL, compared with previous dosage practice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 13:43:07