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Titolo:
Effects of short-acting and long-acting loop diuretics on heart rate variability in patients with chronic compensated congestive heart failure
Autore:
Tomiyama, H; Nakayama, T; Watanabe, G; Shiojima, K; Sakuma, Y; Yamamoto, A; Imai, Y; Yoshida, H; Doba, N;
Indirizzi:
TeikyoJapan, Ichihara Hosp, Dept Internal Med, Div Cardiol, Chiba 2990111,Teikyo Univ Chiba Japan 2990111 nternal Med, Div Cardiol, Chiba 2990111,
Titolo Testata:
AMERICAN HEART JOURNAL
fascicolo: 3, volume: 137, anno: 1999,
pagine: 543 - 548
SICI:
0002-8703(199903)137:3<543:EOSALL>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC PARASYMPATHETIC ACTIVITY; MYOCARDIAL-INFARCTION; FREQUENCY-DOMAIN; SPECTRAL-ANALYSIS; TIME; BLOCKADE; DIGOXIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Tomiyama, H Teikyo Univ, Ichihara Hosp, Dept Internal Med, Div Cardiol, 3426-3 Anesaki, Teikyo Univ 3426-3 Anesaki Chiba Japan 2990111 426-3 Anesaki,
Citazione:
H. Tomiyama et al., "Effects of short-acting and long-acting loop diuretics on heart rate variability in patients with chronic compensated congestive heart failure", AM HEART J, 137(3), 1999, pp. 543-548

Abstract

Background We investigated the effects of a short-acting loop diuretic (furosemide) and a long-acting loop diuretic (azosemide) on heart rate variability, fluid balance, and neurohormonal responses in patients with mild to moderate chronic congestive heart failure. Methods Nineteen patients with mild to moderate chronic congestive heart failure received furosemide (40 to 60 mg/day) or azosemide (60 to 90 mg/day)for 5 days in a crossover manner. We performed time-domain and frequency domain analyses of 24-hour Holter electrocardiographic recordings to assess heart rate variabilityResults The 24-hour urinary sodium excretion was similar during the furosemide and azosemide treatment periods but was significantly greater in the first 2 hours after drug administration during furosemide treatment. Plasma renin activity and the hematocrit level increased and high-frequency power significantly decreased 2 hours after the administration of furosemide only. The standard deviation of all normal R-R intervals and the root mean square of successive differences in the R-R interval were lower with furosemidethan with azosemide (p <.05). Conclusions Furosemide, a short-acting loop diuretic, has a greater influence on heart rate variability and Fluid balance than azosemide, a long-acting loop diuretic, in patients with mild to moderate chronic congestive heart failure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:39:27