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Titolo:
MODULATION OF GLOMERULAR ECTO-ADPASE EXPRESSION BY ESTRADIOL - A HISTOCHEMICAL-STUDY
Autore:
FAAS MM; BAKKER WW; KLOK PA; BALLER JFW; SCHUILING GA;
Indirizzi:
UNIV GRONINGEN,DEPT OBSTET & GYNAECOL,DIV REPROD BIOL,POB 30001 NL-9700 RB GRONINGEN NETHERLANDS UNIV GRONINGEN,DEPT OBSTET & GYNAECOL,DIV REPROD BIOL,DEPT PATHOL NL-9700 RB GRONINGEN NETHERLANDS
Titolo Testata:
Thrombosis and haemostasis
fascicolo: 4, volume: 77, anno: 1997,
pagine: 767 - 771
SICI:
0340-6245(1997)77:4<767:MOGEEB>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET-AGGREGATION; ORAL-CONTRACEPTIVES; ADENOSINE DIPHOSPHATASE; EXPERIMENTAL GLOMERULONEPHRITIS; ANTITHROMBOTIC ACTIVITY; ENDOTHELIAL-CELLS; RAT-KIDNEY; THROMBOREGULATION; COAGULATION; IMPAIRMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
M.M. Faas et al., "MODULATION OF GLOMERULAR ECTO-ADPASE EXPRESSION BY ESTRADIOL - A HISTOCHEMICAL-STUDY", Thrombosis and haemostasis, 77(4), 1997, pp. 767-771

Abstract

The effect of 17-beta-oestradiol (OE2) upon the activity of the glomerular anti-thrombotic ecto-enzyme ADPase was studied in cyclic and ovariectomized (OVX) Wistar rats. On day 0 (i.e. at the time of ovariectomy or 11 days after ovariectomy) rats received OE2-releasing Silastic implants or empty implants and were sacrificed on day 3, 10 or 21. Cryostat kidney sections were histochemically stained for ecto-ADPase activity using enzyme-histochemistry and glomerular reaction product was quantitatively evaluated by computerized image analysis. Both the histological distribution of reaction product in each glomerulus, as reflected by the relative glomerular area covered with reaction product, aswell as enzyme activity, as reflected by staining intensity of the reaction product, were scored. The results show significantly decreased histological distribution after OVX; OVX, however, did not change enzyme activity. It further appeared that OE2 (partly) prevented the decrease of histological distribution in OVX rats, while the enzyme activity was significantly increased by exogenous OE2. In cyclic rats, OE2 did not change histological distribution, although OE2 significantly increased enzyme activity in these rats. It is concluded that glomerular ecto-ADPase expression in the rat kidney is influenced by one or more ovarian factor(s), a very likely candidate being oestradiol. These results may thus point to a dual action of OE2 upon haemostasis: In addition to the known enhancement of procoagulatory plasma factors by OE2, also anti-aggregatory effects may be stimulated by OE2 as reflected byupregulation of vessel wall associated ecto-ADPase activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:21:19