Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Teratological interaction between the bis-triazole antifungal agent fluconazole and the anticonvulsant drug phenytoin
Autore:
Tiboni, GM; Iammarrone, E; Giampietro, F; Lamonaca, D; Bellati, U; Di Ilio, C;
Indirizzi:
Univinecol,unzio, Osped SS Annunziata, Fac Med & Chirurg,Sez Ostetricia & G Univ G DAnnunzio Chieti Italy I-66100 c Med & Chirurg,Sez Ostetricia & G UnivI-66100unzio, Fac Med & Chirurg, Dipartimento Sci Biomed, Sez Biochim,Univ G DAnnunzio Chieti Italy I-66100 artimento Sci Biomed, Sez Biochim,
Titolo Testata:
TERATOLOGY
fascicolo: 2, volume: 59, anno: 1999,
pagine: 81 - 87
SICI:
0040-3709(199902)59:2<81:TIBTBA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
FETAL HYDANTOIN SYNDROME; EXPOSED IN-UTERO; COVALENT BINDING; CARBAMAZEPINE MONOTHERAPY; CONGENITAL-MALFORMATIONS; WARFARIN-FLUCONAZOLE; POTENT INHIBITOR; MICE; TERATOGENICITY; METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Tiboni, GM Univinecol,unzio,i,sped SS Annunziata, Fac Med & Chirurg,Sez Ostetricia & G Univ G DAnnunzio Via Valignani Chieti Italy I-66100 tricia & G
Citazione:
G.M. Tiboni et al., "Teratological interaction between the bis-triazole antifungal agent fluconazole and the anticonvulsant drug phenytoin", TERATOLOGY, 59(2), 1999, pp. 81-87

Abstract

Previous studies implicated the cytochrome P450 (CYP) system as critical in the teratogenic bioactivation of phenytoin (PHT). Fluconazole (FCZ) is anantifungal bis-triazole with potent inhibitory effect on the principal CYP-dependent metabolic pathway of PHT. In this study an in vivo experimental model was used to evaluate the potential ability of FCZ (2, 10, or 50 mg/kgintraperitoneally) to modulate PHT (65 mg/kg intraperitoneally) teratogenesis on day 12 (plug day = day 1) Swiss mice. PHT alone elicited embryocidaland malformative effects, with cleft palate as the major malformation. Pretreatment with the nonembryotoxic dosage of 10 mg FCZ/kg potentiated PHT-induced teratogenesis, as indicated by a twofold (from 6.2% to 13.3%) increment of cleft palate incidence (P < 0.05). Combined treatment with 50 mg FCZ/kg plus PHT resulted in a statistically significant (P < 0.05) increment ofthe resorption incidence recorded after PHT-alone exposure, but possibly as a consequence of the increased embryolethality, in the loss of the potentiative effect on PHT teratogenesis. Although the mechanistic nature of teratological interaction between FCZ and PHT remains to be established, these results may not support CYP system-mediated metabolic conversion as the mechanistic component of PHT teratogenesis. Teratology 59:81-87, 1999. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:03:04