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Titolo:
Diverse T-cell receptor CDR3 length patterns in human CD4(+) and CD8(+) T lymphocytes from newborns and adults
Autore:
Halapi, E; Jeddi-Tehrani, M; Blucher, A; Andersson, R; Rossi, P; Wigzell, H; Grunewald, J;
Indirizzi:
Karolinska Inst, Microbiol & Tumorbiol Ctr, Stockholm, Sweden Karolinska Inst Stockholm Sweden iol & Tumorbiol Ctr, Stockholm, Sweden Univ Med Sci Tehran, Sch Publ Hlth, Dept Immunol, Tehran, Iran Univ Med Sci Tehran Tehran Iran h Publ Hlth, Dept Immunol, Tehran, Iran
Titolo Testata:
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
fascicolo: 2, volume: 49, anno: 1999,
pagine: 149 - 154
SICI:
0300-9475(199902)49:2<149:DTRCLP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-II MOLECULES; GENE SEGMENTS; PERIPHERAL-BLOOD; MONOCLONAL GAMMOPATHY; SARCOIDOSIS PATIENTS; ELDERLY HUMANS; BETA USAGE; CD4+; PEPTIDES; ANTIGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Halapi, E DeCODE Genet Inc, Lynghals 1, IS-110 Reykjavik, Iceland DeCODE Genet Inc Lynghals 1 Reykjavik Iceland IS-110 k, Iceland
Citazione:
E. Halapi et al., "Diverse T-cell receptor CDR3 length patterns in human CD4(+) and CD8(+) T lymphocytes from newborns and adults", SC J IMMUN, 49(2), 1999, pp. 149-154

Abstract

T cells are essential in the initiation and maintenance of immune responses. Specific interaction between T cells and a presumptive antigen occurs through recognition of an MHC-peptide complex by the T-cell receptor (TCR). The complementarity-determining region (CDR) 3 of the TCR has direct contactwith the peptide. Here we describe CDR3 length variability of six different TCRBV gene families of CD4(+) and CD8(+) umbilical cord (UC) and peripheral blood (PB) T cells. Amplified products spanning the TCR CDR3 regions from CD4(+) PB, CD4(+) UC and CD8(+) UC blood T cells typically displayed Gaussian-like distributions. In contrast, profound and frequent perturbations were recorded in CD8(+) PB lymphocytes, with a non-Gaussian pattern in more than half of the samples studied. A substantial portion of the perturbed CD8(+) subsets were clonal or oligoclonal, as determined by CDR3-length restriction, TCRBJ gene usage and nucleotide sequencing. This implies that the conditions for shaping and maintenance of the peripheral TCR repertoire are profoundly different for CD8(+) and CD4(+) T cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:35:17