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Titolo:
SUPPRESSION OF PENTYLENETETRAZOL-INDUCED SEIZURES BY CARNITINE IN MICE
Autore:
YU ZP; IRYO Y; MATSUOKA M; IGISU H; IKEDA M;
Indirizzi:
UNIV OCCUPAT & ENVIRONM HLTH,INST IND ECOL SCI,DEPT ENVIRONM TOXICOL KITAKYUSHU FUKUOKA 807 JAPAN UNIV OCCUPAT & ENVIRONM HLTH,INST IND ECOL SCI,DEPT ENVIRONM TOXICOL KITAKYUSHU FUKUOKA 807 JAPAN UNIV OCCUPAT & ENVIRONM HLTH,INST IND ECOL SCI,DEPT OCCUPAT HLTH ECONKITAKYUSHU FUKUOKA 807 JAPAN
Titolo Testata:
Naunyn-Schmiedeberg's archives of pharmacology
fascicolo: 4, volume: 355, anno: 1997,
pagine: 545 - 549
SICI:
0028-1298(1997)355:4<545:SOPSBC>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTECT MICE; HYPERAMMONEMIA; AMMONIA; NEUROTOXICITY; FAILURE; BRAIN;
Keywords:
CARNITINE; SEIZURES; PENTYLENETETRAZOL; CEREBRAL PROTECTION; BRAIN ENERGY METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
Z.P. Yu et al., "SUPPRESSION OF PENTYLENETETRAZOL-INDUCED SEIZURES BY CARNITINE IN MICE", Naunyn-Schmiedeberg's archives of pharmacology, 355(4), 1997, pp. 545-549

Abstract

When ddY mice were pretreated with L-carnitine (5, 10 or 20 mmol/kg),clonic as well as tonic seizures induced by pentylenetetrazol (PTZ) were dose-dependently suppressed. A time/response study (PTZ was injected 1, 5, 15 or 30 min after L-carnitine) showed that the anticonvulsive effects were apparent when the interval between L-carnitine and PTZ administration was 15-30 min. Saline containing 43% sucrose prolonged the latency to the first clonic seizure but was less effective than 20mmol/kg L-carnitine and did not suppress clonic or tonic seizures. Alterations in brain energy metabolites caused by PTZ including increaseof lactate and decrease of ATP and phosphocreatine were also suppressed by L-carnitine. L-carnitine was more potent than D-carnitine in prolonging the latency to the first clonic seizure and in decreasing the frequency of clonic as well as tonic seizures. The anticonvulsive effects of L-carnitine in PTZ-induced seizures may be unrelated to the transport of long-chain acyl CoA since they were not interfered with by D-carnitine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 18:05:35