Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Early castration-induced upregulation of transforming growth factor beta 1and its receptors is associated with tumor cell apoptosis and a major decline in serum prostate-specific antigen in prostate cancer patients
Autore:
Wikstrom, P; Westin, P; Stattin, P; Damber, JE; Bergh, A;
Indirizzi:
Umea Univ, Dept Urol & Androl, S-90185 Umea, Sweden Umea Univ Umea Sweden S-90185 , Dept Urol & Androl, S-90185 Umea, Sweden Umea Univ, Dept Pathol, S-90185 Umea, Sweden Umea Univ Umea Sweden S-90185 ea Univ, Dept Pathol, S-90185 Umea, Sweden
Titolo Testata:
PROSTATE
fascicolo: 4, volume: 38, anno: 1999,
pagine: 268 - 277
SICI:
0270-4137(19990301)38:4<268:ECUOTG>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT VENTRAL PROSTATE; ESTROGEN-TREATMENT; II RECEPTORS; TGF-BETA; EXPRESSION; DEATH; PROLIFERATION; REGRESSION; ADENOCARCINOMA; FACTOR-BETA-1;
Keywords:
TGF-beta 1; apoptosis; prostate cancer; castration therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Damber, JE Umea Univ, Dept Urol & Androl, S-90185 Umea, Sweden Umea Univ Umea Sweden S-90185 & Androl, S-90185 Umea, Sweden
Citazione:
P. Wikstrom et al., "Early castration-induced upregulation of transforming growth factor beta 1and its receptors is associated with tumor cell apoptosis and a major decline in serum prostate-specific antigen in prostate cancer patients", PROSTATE, 38(4), 1999, pp. 268-277

Abstract

BACKGROUND. The mechanism behind castration-induced apoptosis in prostate cells is unknown, but data from other species suggest that transforming growth factor beta 1 (TGF-beta 1) may be involved. METHODS. By using quantitative RT-PCR and immunohistochemistry, expressionof TGF beta 1 and its receptors type I and II (RI and RII) was studied in normal and tumor areas of core biopsies taken before and 2-11 days after castration therapy. The TGF-beta responses were related to changes in apoptotic index and to changes in serum prostate-specific antigen (PSA). RESULTS. In normal prostate tissue, apoptosis was generally increased by castration, and apoptosis was accompanied by an increase in TGF-beta 1 and RII mRNA levels (P < 0.05). In tumors, apoptosis was seen only in 44% of thecases and in these, but not in the others, TGF-beta 1, RI, and RII mRNA levels were increased (P < 0.05). In the patients showing a prognostically favorable PSA response (nadir PSA <5 ng/ml), but not in the others, RI and RII mRNA levels were significantly upregulated (P < 0.05). CONCLUSIONS. Short-term upregulation of TGF-beta 1 and its receptors is associated with apoptosis in human prostate and prostate cancer, and possiblywith a favorable clinical outcome after castration therapy. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 19:16:12