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Titolo:
Dextromethorphan attenuates ethanol withdrawal syndrome in rats
Autore:
Erden, BF; Ozdemirci, S; Yildiran, G; Utkan, T; Gacar, N; Ulak, G;
Indirizzi:
Kocaeli Univ, Fac Med, Dept Pharmacol, TR-41900 Kocaeli, Turkey Kocaeli Univ Kocaeli Turkey TR-41900 Pharmacol, TR-41900 Kocaeli, Turkey
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 3, volume: 62, anno: 1999,
pagine: 537 - 541
SICI:
0091-3057(199903)62:3<537:DAEWSI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALCOHOL-WITHDRAWAL; DEPENDENCE; TOLERANCE; MORPHINE; ABUSE; ANTAGONISTS; ISCHEMIA; SEIZURES; NEURONS;
Keywords:
dextromethorphan; N-methyl-D-aspartate; ethanol withdrawal; audiogenic seizure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Erden, BF Kocaeli Univ, Fac Med, Dept Pharmacol, TR-41900 Kocaeli, Turkey Kocaeli Univ Kocaeli Turkey TR-41900 TR-41900 Kocaeli, Turkey
Citazione:
B.F. Erden et al., "Dextromethorphan attenuates ethanol withdrawal syndrome in rats", PHARM BIO B, 62(3), 1999, pp. 537-541

Abstract

The effects of dextromethorphan (DM), a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptors, have been investigated on ethanol withdrawal signs in rats. Ethanol (7.2% v/v) was given to rats in a liquid diet for 16 days. DM (10, 20: and 40 mg/kg) and saline were injected intraperitoneally at the third hour of ethanol withdrawal. DM (40 mg/kg) and ethanoldependent saline were also administered to ethanol naive rats. DM (40 mg/kg) did not produce any significant change in locomotor activity in ethanol naive rats. The effects of DM on locomotor activity and total ethanol withdrawal score were evaluated at the fourth and sixth hours of ethanol withdrawal. DM inhibited locomotor hyperactivity at these periods. DM also reducedtotal ethanol withdrawal score from the fourth hour to the sixth hour, andit significantly decreased audiogenic seizures. Seizure susceptibility after chronic ethanol exposure may be dependent upon sensitization or upregulation of NMDA processes and NMDA receptors. Our results suggest that inhibition of NMDA receptors by DM alleviates signs of ethanol withdrawal. (C) 1999 Elsevier Science, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 23:45:50