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Titolo:
Antipsychotic drugs and reproductive hormones: Relationship to body weightregulation
Autore:
Baptista, T; Reyes, D; Hernandez, L;
Indirizzi:
Univ Los Andes, Sch Med, Dept Physiol, Merida, Venezuela Univ Los Andes Merida Venezuela ch Med, Dept Physiol, Merida, Venezuela
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 3, volume: 62, anno: 1999,
pagine: 409 - 417
SICI:
0091-3057(199903)62:3<409:ADARHR>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SULPIRIDE-INDUCED HYPERPROLACTINEMIA; STIMULATES FOOD-INTAKE; LATERAL HYPOTHALAMUS; SYSTEMIC SULPIRIDE; PSYCHOTROPIC-DRUGS; PROLACTIN LEVELS; CLINICAL-TRIAL; SEX-HORMONES; FEMALE RATS; GAIN;
Keywords:
antipsychotics; neuroleptics; obesity; reproductive hormones;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Baptista, T Apartado 93, Merida 5101 A, Venezuela Apartado 93 Merida Venezuela 5101 A Merida 5101 A, Venezuela
Citazione:
T. Baptista et al., "Antipsychotic drugs and reproductive hormones: Relationship to body weightregulation", PHARM BIO B, 62(3), 1999, pp. 409-417

Abstract

Excessive body weight gain is an undesirable side effect of prolonged administration of antipsychotic drugs (AP), which affects health and interfereswith treatment compliance. It has been suggested that hyperprolactinemia-induced endocrine and metabolic abnormalities, particularly in the gonadal steroids, might be involved in the development of this type of weight gain. To test this hypothesis, reproductive hormones, cortisol, dehydro-epiandrosterone-sulfate (DHEA-S), thyroid hormones, and body weight gain were assessed in 18 patients (9 men, 9 women) with mental disorders receiving AP who had been medication-free for at least 3 months before the study, and in 27 placebo-treated subjects (10 men, 17 women). In women, hormones were evaluated during several phases of the menstrual cycle. A significant weight gain was observed in men but not in women. Under AP administration, women displayed significantly lower serum levels of estradiol and progesterone, whereasin men the levels of free testosterone and DHEA-S were significantly lowerthan in controls. Hyperprolactinemia was observed in both sexes. The levels of follicle-stimulating hormone in women and luteinizing hormone in men were significantly elevated by treatment, thus suggesting that the functioning of the hypothalamus-pituitary-gonads was preserved. In men, such an endocrine profile resembles that observed in subjects with primary obesity. Women under AP administration were found to be relatively hyperandrogenic because of decreased serum estradiol levels, whereas women with primary obesityare known to display actual increased levels of androgens. These endocrineabnormalities may contribute to the excessive weight gain observed after AP treatment, and these could be the target of novel pharmacological treatments. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:40:18