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Titolo:
REDUCED LECITHIN - CHOLESTEROL ACYLTRANSFERASE (LCAT) AND NA-PATIENTS(,K+,ATPASE ACTIVITY IN DIABETIC)
Autore:
KIZILTUNC A; AKCAY F; POLAT F; KUSKAY S; SAHIN YN;
Indirizzi:
ATATURK UNIV,SCH MED,DEPT BIOCHEM TR-25240 ERZURUM TURKEY
Titolo Testata:
Clinical biochemistry
fascicolo: 2, volume: 30, anno: 1997,
pagine: 177 - 182
SICI:
0009-9120(1997)30:2<177:RL-CA(>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEINS; POTASSIUM ATPASE ACTIVITY; PERIPHERAL-NERVE; HUMAN-PLASMA; FATTY-ACIDS; INSULIN; MEMBRANE; IDENTIFICATION; SORBITOL; MELLITUS;
Keywords:
DIABETES MELLITUS; NA+,K+,ATPASE; LECITHIN; CHOLESTEROL ACYLTRANSFERASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
A. Kiziltunc et al., "REDUCED LECITHIN - CHOLESTEROL ACYLTRANSFERASE (LCAT) AND NA-PATIENTS(,K+,ATPASE ACTIVITY IN DIABETIC)", Clinical biochemistry, 30(2), 1997, pp. 177-182

Abstract

Objectives: To investigate the plasma concentrations of lecithin:cholesterol acyltransferase (LCAT EC 2.3.1.43) and erythrocyte membrane Na,K+,ATPase and the correlation of these parameters in diabetes mellitus. Design and Methods: Na+,K+,ATPase was measured with spectro-photometric method and LCAT with radioactive method in 19 patients with insulin-dependent diabetes mellitus (IDDM), in 20 with non-insulin-dependent diabetes mellitus (NIDDM) and in 20 healthy volunteers as the control group. Results: Compared with the control group, plasma LCAT concentrations were found to be decreased in both of the patient groups (p <0.01 for both). Erythrocyte membrane Na+,K+,ATPase activities were higher in the controls than both in the NIDDM and IDDM groups (p < 0.01 and p < 0.001, respectively). There were significant correlations between LCAT and Na+,K+,ATPase in IDDM (r = 0.82, p < 0.001) and in NIDDM (r = 0.74, p < 0.001). In order to investigate the effect of cholesterol (C) and lysophosphatidylcholine (LPC) on Na+,K+,ATPase activity, this enzyme's activity was determined in erythrocyte membranes obtained from diabetic subjects after in vitro incubation with increasing concentrations of LPC and C (2-10 mu M). Enzymatic activity was significantly reduced by in vitro C at increasing concentrations but significantly increased by in vitro LPC at increasing concentrations. Conclusions:From these data, it is to be concluded that the decrease in Na+,K+,ATPase activity in diabetes might be due to decreased LCAT concentrations and that may explain the development of atherosclerosis in diabetics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 11:53:32