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Titolo:
Infrequent presence of anti-c-Myc antibodies and absence of c-Myc oncoprotein in sera from lung cancer patients
Autore:
Yamamoto, A; Shimizu, E; Takeuchi, E; Houchi, H; Doi, H; Bando, H; Ogura, T; Sone, S;
Indirizzi:
Univ Tokushima, Sch Med, Dept Internal Med 3, Tokushima 7708503, Japan Univ Tokushima Tokushima Japan 7708503 l Med 3, Tokushima 7708503, Japan Kochi Municipal Hosp, Dept Resp Med, Kochi, Japan Kochi Municipal Hosp Kochi Japan ipal Hosp, Dept Resp Med, Kochi, Japan Tokushima Prefectural Cent Hosp, Dept Resp Med, Tokushima, Japan TokushimaPrefectural Cent Hosp Tokushima Japan p Med, Tokushima, Japan Natl Toneyama Hosp, Dept Internal Med, Osaka, Japan Natl Toneyama Hosp Osaka Japan ma Hosp, Dept Internal Med, Osaka, Japan
Titolo Testata:
ONCOLOGY
fascicolo: 2, volume: 56, anno: 1999,
pagine: 129 - 133
SICI:
0030-2414(1999)56:2<129:IPOAAA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CIRCULATING ANTIBODIES; P53 ANTIBODIES; ONCOGENE; PROTEIN; GENE; ABNORMALITIES; AMPLIFICATION; EXPRESSION; CARCINOMA; FAMILY;
Keywords:
oncogene; auto-antibody; c-Myc; immunoblotting; lung cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Shimizu, E Univ Tokushima, Sch Med, Dept Internal Med 3, Tokushima 7708503, Japan Univ Tokushima Tokushima Japan 7708503 kushima 7708503, Japan
Citazione:
A. Yamamoto et al., "Infrequent presence of anti-c-Myc antibodies and absence of c-Myc oncoprotein in sera from lung cancer patients", ONCOL-BASEL, 56(2), 1999, pp. 129-133

Abstract

To clarify the host immune response and explore a new serological marker of lung cancer, we examined serum c-Myc antigens and auto-antibodies againstc-Myc in 68 lung cancer patients and 30 healthy volunteers using bacterially synthesized glutathione S-transferase c-Myc fusion proteins and immunoblotting. The detection rate of anti-c-Myc antibodies was 13.2% (9/68) in lung cancer patients and 3.3% (1/30) in healthy volunteers. These anti-c-Myc antibodies were directed toward exon 2 alone (4/68), exon 3 alone (1/68), and both exon 2 and exon 3 (4/68) of c-Myc. Circulating c-Myc antigen was notdetected in any individuals with lung cancer and normal controls. Age, sex, performance status, histology, stage, smoking history, and prior treatment of the patients with and without anti-c-Myc antibodies were not significantly different. The low incidence of anti-c-Myc antibodies and c-Myc antigens in peripheral blood suggests that these examinations are not useful in the serological diagnosis of lung cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:11:05