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Titolo:
Low circulating vitamin B-12, B-6 and folate leading to marked hyperhomocysteinemia - associations with premature cerebral and peripheral vascular disease
Autore:
Faccenda, F; Andria, G; Orefice, G; Campanella, G; Cioffi, V; Galasso, R; Guida, L; de Franchis, R; Raineri, L; Rubba, P;
Indirizzi:
Univ&Naples Federico II, Inst Internal Med & Metab Dis, Sch Med, Dept ClinUniv Naples Federico II Naples Italy I-80131 tab Dis, Sch Med, Dept Clin
Titolo Testata:
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
fascicolo: 6, volume: 8, anno: 1998,
pagine: 351 - 356
SICI:
0939-4753(199812)8:6<351:LCVBBA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERIAL OCCLUSIVE DISEASE; TOTAL PLASMA HOMOCYSTEINE; RISK FACTOR; 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE; METHYLENETETRAHYDROFOLATE REDUCTASE; HOMOCYSTINURIA; MUTATION;
Keywords:
hyperhomocysteinemia; methionine loading; vitamins; vascular disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Faccenda, F Univ&Naples Federico II, Inst Internal Med & Metab Dis, Sch Med, Dept Clin Univ Naples Federico II Via S Pansini 5 Naples Italy I-80131
Citazione:
F. Faccenda et al., "Low circulating vitamin B-12, B-6 and folate leading to marked hyperhomocysteinemia - associations with premature cerebral and peripheral vascular disease", NUTR MET CA, 8(6), 1998, pp. 351-356

Abstract

Background and Aim: Hyperhomocysteinemia is an independent risk factor forvascular disease; the known causes of hyperhomocysteinemia include vitaminB-6 and B-12 and folic acid deficiencies. The aim of this study was to investigate the possible role of hyperhomocysteinemia - with special attentionto marked hyperhomocysteinemia - in the development of premature vascular disease, and the extent to which impaired vitamin status may contribute to abnormal homocysteine metabolism. Methods: An oral methionine loading test was performed on 43 patients agedless than 60 years, 24 of whom with cerebrovascular disease (CVD), 10 withperipheral vascular disease (PVD), and 9 with coronary heart disease (CHD), as well as on 25 healthy controls. Results: Marked hyperhomocysteinemia (defined as post load value higher than mean value of controls pills 3 standard deviations, corresponding to 81 mu mol/L) was found in 7 patients (4 CVD and 3 PVD) but in none of the controls (p<0.01). These 7 subjects, who accounted for all of the difference inHey levels between patients and controls, had significantly lower (p<0.01)levels of vitamins B-6, B-12 and folate than did both healthy controls andvascular patients without marked hyperhomocysteinemia. Conclusions: In our study population an association has been shown betweenlow vitamin B concentrations and premature vascular disease (cerebral and peripheral), and this association is mediated by marked hyperhomocysteinemia, as detected by oral methionine loading. (C) 1998, Medikal Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 12:58:07