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Titolo:
Dimethyl sulfoxide increases latency of anoxic terminal negativity in hippocampal slices of guinea pig in vitro
Autore:
Hulsmann, S; Greiner, C; Kohling, R; Wolfer, J; Moskopp, D; Riemann, B; Lucke, A; Wassmann, H; Speckmann, EJ;
Indirizzi:
Univ Munster, Klin & Poliklin Neruochirurg, D-48129 Munster, Germany Univ Munster Munster Germany D-48129 uochirurg, D-48129 Munster, Germany Univ Munster, Inst Physiol, D-48149 Munster, Germany Univ Munster Munster Germany D-48149 t Physiol, D-48149 Munster, Germany
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1-2, volume: 261, anno: 1999,
pagine: 1 - 4
SICI:
0304-3940(19990212)261:1-2<1:DSILOA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPOLARIZATION; POTENTIALS; CHANNELS; ISCHEMIA;
Keywords:
hypoxia; dimethyl sulfoxide; neuroprotection; anoxic terminal negativity; brain slice; hippocampus; DC-potential;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Hulsmann, S UnivHumboldtalleebt Neuro & Sinnesphysiol, Zentrum Physiol & Pathophysiol, Univ Gottingen Humboldtallee 23 Gottingen Germany D-37073 ol,
Citazione:
S. Hulsmann et al., "Dimethyl sulfoxide increases latency of anoxic terminal negativity in hippocampal slices of guinea pig in vitro", NEUROSCI L, 261(1-2), 1999, pp. 1-4

Abstract

Dimethyl sulfoxide (DMSO), which is widely used as a solvent for a varietyof drugs, was used in the present study to investigate its ability to increase the hypoxic tolerance of brain tissue in vitro. DC-potentials and evoked potentials (EP, Schaffer collateral stimulation) were recorded in the CA1 region of hippocampal slices from adult guinea pigs. The latencies of thenegative DC-potential shift (anoxic terminal negativity, ATN) after onset of hypoxia (95% N-2, 5% CO2) were determined during superfusion with artificial cerebrospinal fluid (aCSF) or DMSO 0.4% dissolved in aCSF, respectively. The latencies of ATN were increased by DMSO application from 7.5 +/- 0.9min (mean +/- SEM) under control conditions (n = 38) to 11.1 +/- 1.3 min with DMSO (n = 22, P < 0.01). These results demonstrate a neuroprotective effect of DMSO. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 23:20:58