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Titolo:
An endogenous MPTP-like dopaminergic neurotoxin, N-methyl(R)salsolinol, inthe cerebrospinal fluid decreases with progression of Parkinson's disease
Autore:
Maruyama, W; Abe, T; Tohgi, H; Naoi, M;
Indirizzi:
Inst Appl Biochem, Dept Brain Sci, Gifu 505116, Japan Inst Appl Biochem Gifu Japan 505116 , Dept Brain Sci, Gifu 505116, Japan NatlnInst Longev Sci, Dept Basic Gerontol, Biochem & Metab Lab, Aichi, Japa Natl Inst Longev Sci Aichi Japan ntol, Biochem & Metab Lab, Aichi, Japa Iwate Med Univ, Dept Neurol, Morioka, Iwate, Japan Iwate Med Univ MoriokaIwate Japan v, Dept Neurol, Morioka, Iwate, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 262, anno: 1999,
pagine: 13 - 16
SICI:
0304-3940(19990226)262:1<13:AEMDNN>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
1,2(N)-DIMETHYL-6,7-DIHYDROXYISOQUINOLINIUM ION; 1(R),2(N)-DIMETHYL-6,7-DIHYDROXY-1,2,3,4-TETRAHYDROISOQUINOLINE; N-METHYL-(R)-SALSOLINOL; OXIDATION;
Keywords:
Parkinson's disease; neurotoxin; N-methyl(R)salsolinol; cerebrospinal fluid; biomarker; L-DOPA therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Naoi, M Inst Appl Biochem, Dept Brain Sci, Yagi Mem Pk, Gifu 505116, JapanInst Appl Biochem Yagi Mem Pk Gifu Japan 505116 ifu 505116, Japan
Citazione:
W. Maruyama et al., "An endogenous MPTP-like dopaminergic neurotoxin, N-methyl(R)salsolinol, inthe cerebrospinal fluid decreases with progression of Parkinson's disease", NEUROSCI L, 262(1), 1999, pp. 13-16

Abstract

There have been an increasing number of evidences indicating that dopamine-derived N-methyl(R)salsolinoI is an endogenous MPTP-like neurotoxin to cause Parkinson's disease. In the cerebrospinal fluid from newly diagnosed untreated patients with Parkinson's disease, the level of this toxin was foundto increase significantly, compared to control and a disease control, multiple system atrophy. The effects of the disease duration and the medicationon the level of N-methyl(R)salsolinol were studied from the same patients. After about a 2-year period, the level was significantly reduced. The depletion of dopamine neurons by the disease progression may account for the reduction of the neurotoxin level, whereas L-DOPA therapy did not seem to affect the level of this toxin, even though the enhanced dopamine turnover. The results suggest that N-methyl(R)salsolinol level in the cerebrospinal fluid may indicate remaining dopamine neurons in the parkinsonian brain. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:48:44