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Titolo:
Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells
Autore:
Perl, AK; Dahl, U; Wilgenbus, P; Cremer, H; Semb, H; Christofori, G;
Indirizzi:
Res Inst Mol Pathol, A-1030 Vienna, Austria Res Inst Mol Pathol Vienna Austria A-1030 Pathol, A-1030 Vienna, Austria Umea Univ, Dept Microbiol, S-90187 Umea, Sweden Umea Univ Umea Sweden S-90187 Univ, Dept Microbiol, S-90187 Umea, Sweden Univ Marseille, CNRS,INSERM, IBDM LGPD, Marseille, France Univ Marseille Marseille France RS,INSERM, IBDM LGPD, Marseille, France
Titolo Testata:
NATURE MEDICINE
fascicolo: 3, volume: 5, anno: 1999,
pagine: 286 - 291
SICI:
1078-8956(199903)5:3<286:REONCA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-CAM; DIFFERENTIAL EXPRESSION; NEURITE OUTGROWTH; POLYSIALIC ACID; NERVOUS-SYSTEM; GROWTH-FACTOR; NCAM; ISLETS; TUMORIGENESIS; AGGREGATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Christofori, G Res Inst Mol Pathol, Dr Bohr Gasse 7, A-1030 Vienna, Austria Res Inst Mol Pathol Dr Bohr Gasse 7 Vienna Austria A-1030
Citazione:
A.K. Perl et al., "Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells", NAT MED, 5(3), 1999, pp. 286-291

Abstract

As in the development of many human cancers, in a transgenic mouse model of beta-cell carcinogenesis (Rip1Tag2), expression of neural cell adhesion molecule (NCAM) changes from the 120-kDa isoform in normal tissue to the 140/180-kDa isoforms in tumors. NCAM-deficient Rip1Tag2 mice, generated by crossing Rip1Tag2 mice with NCAM knockout mice, develop metastases, a tumor stage that is not seen in normal Rip1Tag2 mice. In contrast, overexpression of NCAM 120 in NCAM-deficient Rip1Tag2 mice prevents tumor metastasis. The results indicate that the loss of NCAM-mediated cell adhesion is one rate-limiting step in the actual metastatic dissemination of beta tumor cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:50:38