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Titolo:
Comparison of evoked cortical activity in conscious and propofol-anesthetized rats using functional MRI
Autore:
Lahti, KM; Ferris, CF; Li, FH; Sotak, CH; King, JA;
Indirizzi:
Univ Massachusetts, Med Ctr, Dept Psychiat, Sch Med,Behav Neurosci Program, Univ Massachusetts Worcester MA USA 01655 Sch Med,Behav Neurosci Program, Univ Massachusetts, Sch Med, Dept Radiol, Worcester, MA 01655 USA Univ Massachusetts Worcester MA USA 01655 Radiol, Worcester, MA 01655 USA Worcester Polytech Inst, Dept Biomed Engn, Worcester, MA 01609 USA Worcester Polytech Inst Worcester MA USA 01609 n, Worcester, MA 01609 USA Mem Hlth Care, Dept Neurol, Worcester, MA USA Mem Hlth Care Worcester MA USA Hlth Care, Dept Neurol, Worcester, MA USA
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 2, volume: 41, anno: 1999,
pagine: 412 - 416
SICI:
0740-3194(199902)41:2<412:COECAI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CEREBRAL GLUCOSE-UTILIZATION; ALPHA-CHLORALOSE; SOMATOSENSORY STIMULATION; NITROUS-OXIDE; BLOOD-FLOW; ANESTHESIA; BRAIN; METABOLISM; HALOTHANE;
Keywords:
functional magnetic resonance imaging; nuclear magnetic resonance imaging; neuroimaging; cerebral blood flow; sensory motor cortex; blood oxygenation level-dependent (BOLD); general anesthesia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: King, JA Univ Massachusetts, Med Ctr, Dept Psychiat, Sch Med,Behav Neurosci Program, Univ Massachusetts 55 Lake Ave N Worcester MA USA 01655 Program,
Citazione:
K.M. Lahti et al., "Comparison of evoked cortical activity in conscious and propofol-anesthetized rats using functional MRI", MAGN RES M, 41(2), 1999, pp. 412-416

Abstract

Changes in cortical activity during foot shock were assessed under conscious and propofol-anesthetized conditions using functional magnetic resonanceimaging (fMRI), Increases in signal intensity were observed in the contralateral somatosensory cortex in response to electrical shock of the hindpaw under bath conditions, These increases in cortical signal ranged from 6% to26% while awake and from 1% to 6% under propofol anesthesia. In each of the six animals studied, the largest Increase in blood oxygenation level-dependent (BOLD)-based signal intensity was observed during consciousness. In three of six animals, propofol anesthesia depressed signal intensity by as much as 10-fold, showing that the level of cortical activity during foot shock is dampened by anesthesia. These results indicate it would be advantageous to use fully conscious animals to maximize BOLD-based MRI signal in certain behavioral studies using MR spectrometers with modest field strengths (1.0-2.0 T). (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 11:13:27