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Titolo:
Effects of water exchange on the measurement of myocardial perfusion usingparamagnetic contrast agents
Autore:
Judd, RM; Reeder, SB; May-Newman, K;
Indirizzi:
Northwestern Univ, Sch Med, Feinberg Cardiovasc Res Inst, Chicago, IL 60611 Northwestern Univ Chicago IL USA 60611 iovasc Res Inst, Chicago, IL 60611 Johns Hopkins Med Inst, Baltimore, MD 21287 USA Johns Hopkins Med Inst Baltimore MD USA 21287 st, Baltimore, MD 21287 USA
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 2, volume: 41, anno: 1999,
pagine: 334 - 342
SICI:
0740-3194(199902)41:2<334:EOWEOT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-VOLUME; GD-DTPA; SPIN RELAXATION; TRANSIT-TIME; INFARCTION; 1ST-PASS; TISSUE; ENHANCEMENT; TOMOGRAPHY; MUSCLE;
Keywords:
myocardial perfusion; magnetic resonance imaging; contrast agents;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Judd, RM Northwestern,Tarry Sch Med, Feinberg Cardiovasc Res Inst, 303 E Chicago Ave Northwestern Univ 303 E Chicago Ave,Tarry 12-703 Chicago IL USA 60611
Citazione:
R.M. Judd et al., "Effects of water exchange on the measurement of myocardial perfusion usingparamagnetic contrast agents", MAGN RES M, 41(2), 1999, pp. 334-342

Abstract

To investigate the effects of water exchange on quantification of perfusion, data were acquired in isolated hearts (n = 11) and used to develop a model of exchange. Myocardial T-1 was measured 3 times/sec during step changesin concentration of intravascular (polylysine-gadolinium-diethylene-triamine-pentaacetic acid) and extracellular (gadoteridol) agents. For the intravascular agent, the change in 1/T-1 (Delta R-1) was lower than predicted by fast exchange (2.7 +/- 0.5 vs, 7.8 sec(-1), respectively), and suggested anintra-extravascular exchange rate of 3 Hz, For the extracellular agent, contrast kinetics were similar to those of similarly sized molecules (wash-intime constant 38 +/- 5 sec), and the data suggested fast interstitial-cellular exchange. Modeling showed that perfusion is underestimated for both agents if exchange is ignored, although the relationships of measured to actual perfusion were monotonic, We conclude that myocardial water exchange strongly affects first-pass enhancement but that ignoring the effects of exchange may still provide reasonable estimates of regional perfusion differences. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 05:42:25