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Titolo:
Perfusion analysis using dynamic arterial spin labeling (DASL)
Autore:
Barbier, EL; Silva, AC; Kim, HJ; Williams, DS; Koretsky, AP;
Indirizzi:
CarnegieSAellon Univ, Pittsburgh NMR Ctr Biomed Res, Pittsburgh, PA 15213 U Carnegie Mellon Univ Pittsburgh PA USA 15213 Res, Pittsburgh, PA 15213 U Carnegie Mellon Univ, Dept Biol Sci, Pittsburgh, PA 15213 USA Carnegie Mellon Univ Pittsburgh PA USA 15213 ci, Pittsburgh, PA 15213 USA Carnegie Mellon Univ, Dept Chem, Pittsburgh, PA 15213 USA Carnegie Mellon Univ Pittsburgh PA USA 15213 em, Pittsburgh, PA 15213 USA
Titolo Testata:
MAGNETIC RESONANCE IN MEDICINE
fascicolo: 2, volume: 41, anno: 1999,
pagine: 299 - 308
SICI:
0740-3194(199902)41:2<299:PAUDAS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; MAGNETIZATION-TRANSFER; MR-ANGIOGRAPHY; RAT-BRAIN; WATER; INVERSION; TIME; ECHO; VOLUME;
Keywords:
cerebral blood flow; MR; hypercapnia; transit time; frequency filtering;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Koretsky, AP Carnegiegh,llon Univ, Pittsburgh NMR Ctr Biomed Res, 4400 5thAve, Pittsbur Carnegie Mellon Univ 4400 5th Ave Pittsburgh PA USA 15213 bur
Citazione:
E.L. Barbier et al., "Perfusion analysis using dynamic arterial spin labeling (DASL)", MAGN RES M, 41(2), 1999, pp. 299-308

Abstract

A variety of magnetic resonance (MR) techniques have proved useful to quantify perfusion using endogenous water as a blood flow tracer. Assuming thatwater is a freely diffusable tracer, the model used for these techniques predicts that the quantitation of perfusion is based on three parameters, all of which can depend on blood flow. These are the longitudinal tissue relaxation time, the transit time from point of labeling to tissue, and the difference in tissue MR signal between an appropriate control and the labeled state. To measure these three parameters in parallel, a dynamic arterial spin labeling (DASL) technique is introduced based on the analysis of the tissue response to a periodic time varying degree of arterial spin labeling, called here the labeling function (LF), The LF frequency can be modulated tooverdetermine parameters necessary to define the system. MR schemes are proposed to measure the tissue response to different LF frequencies efficiently. Sprague-Dawley rats were studied by DASL, using various frequencies forthe LF and various arterial pCO(2) levels. During data processing, the periodic behavior of the tissue response to the LF allowed for frequency filtering of periodic changes in signal intensity unrelated to perfusion and arterial spin labeling. Measures of transit time, tissue longitudinal relaxation time, and perfusion agreed well over a range of LF frequencies and with previous results. DASL shows potential for more accurately quantifying perfusion as well as measuring transit times associated with arterial spin labeling techniques. (C) 1999 Wiley-Liss, Inc.

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Documento generato il 24/11/20 alle ore 14:33:03