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Titolo:
Endogenous catecholamine synthesis, metabolism, storage and uptake in human neutrophils
Autore:
Cosentino, M; Marino, F; Bombelli, R; Ferrari, M; Lecchini, S; Frigo, G;
Indirizzi:
Univese,ia, Dept Internal Med & Therapeut, Clin Pharmacol Sect, I-21100 Var Univ Pavia Varese VA Italy I-21100 peut, Clin Pharmacol Sect, I-21100 Var InnsbruckInnsbruck,t Internal Med & Therapeut, Clin Pharmacol Sect, A-6020Innsbruck Univ Innsbruck Austria A-6020 eut, Clin Pharmacol Sect, A-6020
Titolo Testata:
LIFE SCIENCES
fascicolo: 11, volume: 64, anno: 1999,
pagine: 975 - 981
SICI:
0024-3205(19990205)64:11<975:ECSMSA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-ADRENERGIC RECEPTORS; LYSOSOMAL ENZYME RELEASE; POLYMORPHONUCLEAR LEUKOCYTES; CYCLIC-AMP; CELLS; LYMPHOCYTES; INHIBITION; EPINEPHRINE; MEMBRANES; BINDING;
Keywords:
catecholamines; neutrophils; human; alpha-methyl-p-tyrosine; pargyline; reserpine; desipramine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Frigo, G UnivoPavia, Dept Internal Med & Therapeut, Clin Pharmacol Sect, Via Ottorin Univ Pavia Via Ottorino Rossi N9 Varese VA Italy I-21100 Ottorin
Citazione:
M. Cosentino et al., "Endogenous catecholamine synthesis, metabolism, storage and uptake in human neutrophils", LIFE SCI, 64(11), 1999, pp. 975-981

Abstract

Evidence is presented that human neutrophils contain catecholamines and several of their metabolites. In vitro, incubation with a-methyl-p-tyrosine or pargyline affects intracellular dopamine, norepinephrine and their metabolites, suggesting catecholamine synthesis and degradation by these cells. Reserpine reduces intracellular dopamine and norepinephrine and desipramine reduces intracellular norepinephrine, suggesting the presence of storage and uptake mechanism. In view of the ability of catecholamines to affect neutrophil function, the present results support the hypothesis that autoregulatory adrenergic mechanisms may exist in these cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 18:23:18