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Titolo:
Activation of the kallikrein-kinin system in hemodialysis: Role of membrane electronegativity, blood dilution, and pH
Autore:
Renaux, JL; Thomas, M; Crost, T; Loughraieb, N; Vantard, G;
Indirizzi:
Hosp R&D Int, F-69357 Lyon 07, France Hosp R&D Int Lyon France 07Hosp R&D Int, F-69357 Lyon 07, France
Titolo Testata:
KIDNEY INTERNATIONAL
fascicolo: 3, volume: 55, anno: 1999,
pagine: 1097 - 1103
SICI:
0085-2538(199903)55:3<1097:AOTKSI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING-ENZYME-INHIBITORS; ANAPHYLACTOID REACTIONS; HYPERSENSITIVITY REACTIONS; DIALYSIS MEMBRANES; ACE INHIBITORS; AN69 MEMBRANES; BRADYKININ;
Keywords:
dialysis membrane; bradykinin; contact system of plasma; angiotensin-converting-enzyme inhibition; dialysate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Renaux, JL Hosp R&D Int, 61 Ave Tony Garnier, F-69357 Lyon 07, France HospR&D Int 61 Ave Tony Garnier Lyon France 07 yon 07, France
Citazione:
J.L. Renaux et al., "Activation of the kallikrein-kinin system in hemodialysis: Role of membrane electronegativity, blood dilution, and pH", KIDNEY INT, 55(3), 1999, pp. 1097-1103

Abstract

Background. The kallikrein-kinin system activation by contact with a negatively charged surface has been promulgated to be responsible for hypersensitivity reactions. However, to explain the low frequency and heterogeneity of hypersensitivity reactions, we hypothesized that not only the electronegativity of the membrane, but also other physicochemical parameters could influence the activation of the contact phase system of plasma assessed by themeasurement of kallikrein activity and bradykinin concentration. Methods. Plasma kallikrein activity using chromogenic substrate (S2302) and plasma bradykinin concentration (enzyme immune assay) were measured during the perfusion of human plasma (2.5 ml/min) through minidialyzers mounted with six different membranes [polyacrylonitrile (PAN) from Asahi (PANDX) and from Hospal (AN69), polymethylmethacrylate (PMMA) from Toray, cellulose triacetate (CT) from Baxter, cuprophane (CUP) from Akzo and polysulfone (PS)from Fresenius]. Results. A direct relationship was shown between the electronegativity of the membrane assessed by its zeta potential and the activation of plasma during the first five minutes of plasma circulation. With the AN69 membrane, the detection of a kallikrein activity in diluted plasma but not in undiluted samples confirmed the importance of a protease-antiprotease imbalance leading to bradykinin release during the first five minutes of dialysis. WithPAN membranes, the use of citrated versus heparinized plasma and the use of various rinsing solutions clearly show a dramatic effect of pH on the kallikrein activity and the bradykinin concentration measured in plasma. Finally, increasing the zeta potential of the membrane leads to a significant increase of plasma kallikrein activity and bradykinin concentration. Conclusions. Our in vitro experimental approach evidences the importance of the control of these physicochemical factors to decrease the activation of the contact system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 03:05:30