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Titolo:
TP5 triggers signal transduction involving mitogen activated protein kinases in monocytes
Autore:
Gonser, S; Crompton, NEA; Weber, PJA; Beck-Sickinger, AG; Folkers, G;
Indirizzi:
ETH Zurich, Dept Pharm, CH-8057 Zurich, Switzerland ETH Zurich Zurich Switzerland CH-8057 Pharm, CH-8057 Zurich, Switzerland Paul Scherrer Inst, CH-5232 Villigen, Switzerland Paul Scherrer Inst Villigen Switzerland CH-5232 32 Villigen, Switzerland
Titolo Testata:
JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH
fascicolo: 1-4, volume: 19, anno: 1999,
pagine: 155 - 166
SICI:
1079-9893(199901/07)19:1-4<155:TTSTIM>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYPEPTIDE HORMONE; THYMOPOIETIN; THYMOPENTIN; THYMUS; DIFFERENTIATION; CANCER; CELLS; CDNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Gonser, S ETH Zurich, Dept Pharm, Winterthurerstr 190, CH-8057 Zurich, Switzerland ETH Zurich Winterthurerstr 190 Zurich Switzerland CH-8057 rland
Citazione:
S. Gonser et al., "TP5 triggers signal transduction involving mitogen activated protein kinases in monocytes", J RECEPT SI, 19(1-4), 1999, pp. 155-166

Abstract

The pentapetide thymopentin (TP5) corresponding to the aminoacids RKDVY represents the residues 32 - 36 of thymopoietin (TP), which was originally isolated from bovine thymus. Both were observed to induce T-cell differentiation and maturation. Recently however it was shown, that TP represents the N-terminal 49 aa of the human thymopoietin (TMPO) isoforms TMPO alpha, beta and gamma, which are localized in the nucleus. TP5 was investigated in a variety of diseases and showed efficacy by improving the immune balance, whereby different cells increased in cell number or activity. Findings which support the assumption of multifunctional efficacy and a description of TP and TP5 modulating T cells lack any interpretation on molecular level. In thepresent study we investigated the binding of TP5 on white blood cells. We identified monocytes and neutrophils as TP5-binding cells by displacing fluorescein-labelled TP5 with an excess of unlabelled TP5 in competition assays. Binding of TP5 on cell surface proteins resulted in cellular signalling and we report here that TP5 triggers signal transduction involving mitogen activated protein kinases p42/p44 (MAPKs) in monocytes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:39:29