Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Fluorine-18 radiolabelling, biodistribution studies and preliminary pet evaluation of a new memantine derivative for imaging the NMDA receptor
Autore:
Ametamey, SM; Samnick, S; Leenders, KL; Vontobel, P; Quack, G; Parsons, CG; Schubiger, PA;
Indirizzi:
ETHSwitzerlandul Scherrer Inst, Ctr Radiopharmaceut Sci, CH-5232 Villigen,ETH Zurich Villigen Switzerland CH-5232 harmaceut Sci, CH-5232 Villigen, Univ Zurich Hosp, Div Nucl Med, CH-5232 Villigen, Switzerland Univ Zurich Hosp Villigen Switzerland CH-5232 5232 Villigen, Switzerland Paul Scherrer Inst, PET Program, CH-5232 Villigen, Switzerland Paul Scherrer Inst Villigen Switzerland CH-5232 32 Villigen, Switzerland Merz & Co GMBH Co, D-60318 Frankfurt, Germany Merz & Co GMBH Co Frankfurt Germany D-60318 , D-60318 Frankfurt, Germany
Titolo Testata:
JOURNAL OF RECEPTOR AND SIGNAL TRANSDUCTION RESEARCH
fascicolo: 1-4, volume: 19, anno: 1999,
pagine: 129 - 141
SICI:
1079-9893(199901/07)19:1-4<129:FRBSAP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGMA-RECEPTORS; RAT-BRAIN; COMPLEX; ACID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Ametamey, SM ETHSwitzerlandul Scherrer Inst, Ctr Radiopharmaceut Sci, CH-5232 Villigen, ETH Zurich Villigen Switzerland CH-5232 , CH-5232 Villigen,
Citazione:
S.M. Ametamey et al., "Fluorine-18 radiolabelling, biodistribution studies and preliminary pet evaluation of a new memantine derivative for imaging the NMDA receptor", J RECEPT SI, 19(1-4), 1999, pp. 129-141

Abstract

A synthetic method has been established for preparing [F-18]1-amino-3-fluoromethyl-5-methyl-adamantane ([F-18]AFA). Biodistrubution of the radiotracer; in mice showed high brain uptake. The peak uptake (3.78 I.D/g organ) forthe brain occurred at 30 min after injection. Accumulation of radioactivity in mouse brain was consistent with the known distribution of the NMDA receptors. The binding of [F-18]AFA to the phencyclidine (PCP) binding sites of the NMDA receptor complex and the sigma recognition sites in a Rhesus monkey was also examined using positron emission tomography (PET). The regional brain distribution of [F-18]AFA was changed by memantine and by (+)-MK-801, indicating competition for the same binding sites. Treatment with haloperidol caused a marked reduction of radioactivity uptake in all the brain regions examined. (-)-Butaclamol, which has pharmacological specificity for sigma sites, did not have any significant effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 01:22:43