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Titolo:
Expression of E-cadherin in oral cancer cell lines and its relationship toinvasiveness in SCID mice in vivo
Autore:
Hoteiya, T; Hayashi, E; Satomura, K; Kamata, N; Nagayama, M;
Indirizzi:
Univ04,kushima, Sch Dent, Dept Oral & Maxillofacial Surg 1, Tokushima 77085 Univ Tokushima Tokushima Japan 7708504 llofacial Surg 1, Tokushima 77085
Titolo Testata:
JOURNAL OF ORAL PATHOLOGY & MEDICINE
fascicolo: 3, volume: 28, anno: 1999,
pagine: 107 - 111
SICI:
0904-2512(199903)28:3<107:EOEIOC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR RECEPTOR; ADHESION MOLECULES; CATENIN COMPLEX; NUDE-MICE; IN-VITRO; METASTASIS; CARCINOMAS; GENE; FIBROBLASTS; TISSUES;
Keywords:
cell line; E-cadherin; invasion; oral cancer; SCID-mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Hoteiya, T UnivoTokushima, Sch Dent, Dept Oral & Maxillofacial Surg 1, 3-18-15 Kuramot Univ Tokushima 3-18-15 Kuramoto Cho Tokushima Japan 7708504 ot
Citazione:
T. Hoteiya et al., "Expression of E-cadherin in oral cancer cell lines and its relationship toinvasiveness in SCID mice in vivo", J ORAL PATH, 28(3), 1999, pp. 107-111

Abstract

We examined the expression of E-cadherin in nine oral cancer cell lines. HSC-4, NA, ZA, HOC927 and Ca9-22 cells strongly expressed E-cadherin [E-CD(+) cell line] and HSC-2 and HSC-3 cells weakly expressed E-cadherin [E-CD(+) cell line]. All the cell lines that expressed E-cadherin were of cuboidalmorphology and formed cobblestone colonies. In contrast, TSU and HOC313 cells had spindle shapes, formed dispersed colonies, and were completely negative for E-cadherin [E-CD(-) cell line]. Moreover, all cell lines that expressed E-cadherin showed tumorgenicity in SCID mice, but E-CD(-) cell lines did not show tumorgenicity. The tumors derived from E-CD(+) cell lines invaded deeper into the connective tissues than those from E-CD(++) cell lines. In immunohistochemical analysis, the difference was more marked at the edges of the cancer nests. These results suggest that E-cadherin expression was relevant to the cell forms and the differential grade of cultured cells and that reduced E-cadherin in oral cancer may be associated with invasiveness in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 03:13:23