Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The effects of progesterone on oxytocin mRNA levels in the paraventricularnucleus of the female rat can be altered by the administration of diazepamor RU486
Autore:
Thomas, A; Shughrue, PJ; Merchenthaler, I; Amico, JA;
Indirizzi:
Univ15261sburgh, Sch Med, Div Endocrinol & Metab, Dept Med, Pittsburgh, PAUniv Pittsburgh Pittsburgh PA USA 15261 & Metab, Dept Med, Pittsburgh, PA Dept Vet Affairs Med Ctr, Pittsburgh, PA 15261 USA Dept Vet Affairs Med Ctr Pittsburgh PA USA 15261 Pittsburgh, PA 15261 USA Wyeth Ayerst Res, Womens Hlth Res Inst, Radnor, PA 19087 USA Wyeth Ayerst Res Radnor PA USA 19087 Hlth Res Inst, Radnor, PA 19087 USA
Titolo Testata:
JOURNAL OF NEUROENDOCRINOLOGY
fascicolo: 2, volume: 11, anno: 1999,
pagine: 137 - 144
SICI:
0953-8194(199902)11:2<137:TEOPOO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RIBONUCLEIC-ACID; CENTRAL-NERVOUS-SYSTEM; GUINEA-PIG BRAIN; INSITU HYBRIDIZATION; IMMUNOCYTOCHEMICAL LOCALIZATION; RECEPTOR IMMUNOREACTIVITY; MEDIOBASAL HYPOTHALAMUS; SYNTHETIC PROGESTIN; MATERNAL-BEHAVIOR; GONADAL-STEROIDS;
Keywords:
gamma aminobutyric acid; hypothalamus; neurohypophysis; oxytocin; progesterone; steroid receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Amico, JA UniviPittsburgh, Sch Med, Div Endocrinol & Metab, Dept Med, E1140 Biomed Sc Univ Pittsburgh E1140 Biomed Sci Tower Pittsburgh PA USA 15261 c
Citazione:
A. Thomas et al., "The effects of progesterone on oxytocin mRNA levels in the paraventricularnucleus of the female rat can be altered by the administration of diazepamor RU486", J NEUROENDO, 11(2), 1999, pp. 137-144

Abstract

Oxytocin (OT) facilitates the onset of maternal behaviour in the late pregnant rat, enhances uterine contractility at parturition, and elicits milk ejection during lactation. If the rising estradiol (E-2) and declining progesterone (P) of late pregnancy is reproduced in a virgin ovariectomized rat by implanting E-2- and P-filled capsules for 2 weeks followed by removal ofP-containing implants 36-48 h prior to death, OT messenger ribonucleic acid (mRNA) levels increase in the paraventricular and supraoptic nuclei (PVN and SON) of the rat. Both E-2 administration and P withdrawal are necessaryto increase OT mRNA, but the mechanisms of these effects are not understood. P may work within the PVN although P receptors are reported to be sparseor non-existent in the PVN or outside the PVN on PR-containing neurones that project to OT-containing neurones or via membrane bound receptors that are known to bind neurosteroids and gamma aminobutyric acid (GABA). To determine the mechanism through which P may inhibit or P withdrawal may increaseOT mRNA levels, virgin ovariectomized (OVX) rats received sequential E-2 and P via Silastic implants for 14 days. On day 13, prior to removal of P capsules on day 14, the rats were given the benzodiazepine agonist, diazepam,or saline injections subcutaneously (s.c.) twice daily until death on day 16. OT mRNA levels were increased in the steroid-treated group that received saline but not diazepam. In experiment 2, P capsules were removed on day 14 or pharmacological P withdrawal was induced by injecting RU486 injections s.c. twice daily until death 48 h later. OT mRNA levels were increased inthe steroid-treated group that received RU486. Subsequent studies demonstrated the expression of PR mRNA within the rat PVN. The data suggest that gonadal steroids may influence PVN OT mRNA levels by modulating the GABA(A) receptor or by directly altering gene transcription via the PR.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 07:58:38