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Titolo:
Merkel cells are responsible for the initiation of taste organ morphogenesis in the frog
Autore:
Toyoshima, K; Seta, Y; Toyono, T; Takeda, S;
Indirizzi:
Kyushukuoka Coll, Dept Oral Anat & Neurobiol, Kokurakita Ku, Kitakyushu, Fu Kyushu Dent Coll Kitakyushu Fukuoka Japan 8038580 kita Ku, Kitakyushu, Fu
Titolo Testata:
JOURNAL OF COMPARATIVE NEUROLOGY
fascicolo: 1, volume: 406, anno: 1999,
pagine: 129 - 140
SICI:
0021-9967(19990329)406:1<129:MCARFT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURON-SPECIFIC ENOLASE; SEROTONIN-LIKE IMMUNOREACTIVITY; CONTAINING BASAL CELLS; NERVE GROWTH-FACTOR; CUTANEOUS MECHANORECEPTORS; RANA-CATESBEIANA; FINE-STRUCTURE; MESSENGER-RNA; BUDS DEVELOP; TOUCH DOMES;
Keywords:
development; serotonin; gustatory; Merkel cells; salientia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Toyoshima, K Kyushukuoka Coll, Dept Oral Anat & Neurobiol, Kokurakita Ku, Kitakyushu, Fu Kyushu Dent Coll Kitakyushu Fukuoka Japan 8038580 kyushu, Fu
Citazione:
K. Toyoshima et al., "Merkel cells are responsible for the initiation of taste organ morphogenesis in the frog", J COMP NEUR, 406(1), 1999, pp. 129-140

Abstract

Taste organs in the frog have a distinctive cell type located exclusively in the basal portion. In the same fashion as type III cells in mammalian taste buds, these basal cells show immunoreactivity for serotonin antibody. Further, these cells are morphologically similar to epidermal Merkel cells. To determine the significance of these serotonergic basal cells, we examined the early development of taste organs during metamorphosis of the frog byfocusing on the origin and possible roles of serotonergic basal cells. Forconvenience of description, five stages of development (metamorphic stage to climax stages A-D) are defined. In the metamorphic stage, a few noninnervated Merkel cells appear at the upper layer of the lingual epithelium. No neuronal elements are seen in the epithelium at this stage. At climax stages A-B, immature fungiform papillae become discernible in the dorsal surfaceof the tongue, where the Merkel cells are located. Merkel cells then move downward and extend their cytoplasmic processes toward the basal lamina. These cells are identified by their intense immunoreactivity for serotonin. During the later stages, many nerve fibers in the subepithelial connective tissue approach the epithelium containing Merkel cells. At climax stages C-D, Merkel cells extend cytoplasmic processes along the basal lamina toward the center of the newly forming fungiform papillae. The morphology of these Merkel cells exactly coincides with that of serotonergic basal cells in adult taste organs. Profuse exocytotic release of dense-cored granules of Merkel cells toward the nerve fibers through the basal lamina is frequently seen in these stages. The present study indicates that serotonergic basal cells are derived from intraepithelial Merkel cells, which act as target sites for growing nerves and may be responsible for the initiation of taste organmorphogenesis. J. Comp. Neurol. 406:129-140, 1999. (C) 1999 Wiley-Liss, Inc.

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Documento generato il 22/10/20 alle ore 02:33:52