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Titolo:
Comparison of irbesartan with captopril effects on cardiac hypertrophy andgene expression in heart failure-prone male SHHF/Mcc-fa(cp) rats
Autore:
Carraway, JW; Park, S; McCune, SA; Holycross, BJ; Radin, MJ;
Indirizzi:
Ohio State Univ, Dept Vet Biosci, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 Vet Biosci, Columbus, OH 43210 USA Ohio State Univ, Dept Food Sci & Technol, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 i & Technol, Columbus, OH 43210 USA Ohio State Univ, Dept Med Biochem, Columbus, OH 43210 USA Ohio State UnivColumbus OH USA 43210 Med Biochem, Columbus, OH 43210 USA
Titolo Testata:
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
fascicolo: 3, volume: 33, anno: 1999,
pagine: 451 - 460
SICI:
0160-2446(199903)33:3<451:COIWCE>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATRIAL-NATRIURETIC-PEPTIDE; RECEPTOR ANTAGONIST; GLUCOSE-METABOLISM; HYPERTENSIVE RATS; MYOSIN; LOSARTAN; BLOCKADE; THERAPY;
Keywords:
angiotensin-converting enzyme inhibitors angiotensin II subtype 1 receptorantagonist; cardiac hypertrophy; hypertension; atrial natriuretic peptide; SHHF/Mcc-fa(cp) rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Radin, MJ Ohio State Univ, Dept Vet Biosci, 1925 Coffey Rd, Columbus, OH 43210 USA Ohio State Univ 1925 Coffey Rd Columbus OH USA 43210 H 43210 USA
Citazione:
J.W. Carraway et al., "Comparison of irbesartan with captopril effects on cardiac hypertrophy andgene expression in heart failure-prone male SHHF/Mcc-fa(cp) rats", J CARDIO PH, 33(3), 1999, pp. 451-460

Abstract

Angiotensin-converting enzyme (ACE) inhibitors have proven an effective means to control hypertension and manage cardiac hypertrophy. It is presentlyunknown if newer specific angiotensin II subtype 1 receptor (AT(1)R) antagonists are as effective or more effective in treating these conditions compared with ACE inhibitors. There is evidence that these classes of drugs mayaffect cardiac hypertrophy by different mechanisms. This study compared the effect of irbesartan, an AT1R antagonist, with that of captopril, an ACE inhibitor, on expression of early genetic markers of cardiac hypertrophy inlean male SHHF/Mcc-fa(cp) rats. SHHF\Mcc-fa(cp) rats (n = 10/group) were given captopril (100 mg/kg/day), irbesartan (50 mg/kg/day), or placebo for 16 weeks. Irbesartan and captopril significantly reduced systolic pressure and produced similar rightward shifts in the angiotensin I dose-response curve. Renal renin gene expression was increased 8.6-fold by irbesartan and 17.7-fold by captopril. The only effect on echocardiographic findings was a similar decrease in aortic peak velocity, an index of systolic function, by both treatments. Early markers of cardiac hypertrophy were significantly attenuated by both drugs. Both drugs produced marked and equivalent reductions in left ventricular atrial natriuretic peptide (ANP) messenger RNA (mRNA)levels compared with controls. This decrease in ANP gene expression was accompanied by a decrease in plasma ANP concentration in the treatment groups. The shift from V-1 to V-3 myosin isozymes was similarly decreased in bothtreatment groups, compared with controls. These data suggest that captopril and irbesartan are similarly effective in controlling expression of genesassociated with ventricular hypertrophy in heart failure-prone SHHF/Mcc-fa(cp) rat.

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Documento generato il 24/11/20 alle ore 12:58:17