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Titolo:
MECHANISMS INVOLVED IN NATURAL-KILLER-CELL MEDIATED TARGET-CELL DEATHLEADING TO SPONTANEOUS TUMOR-REGRESSION
Autore:
KHAR A;
Indirizzi:
CTR CELLULAR & MOL BIOL,UPPAL RD HYDERABAD 500007 ANDHRA PRADESH INDIA
Titolo Testata:
Journal of Biosciences
fascicolo: 1, volume: 22, anno: 1997,
pagine: 23 - 31
SICI:
0250-5991(1997)22:1<23:MIINMT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUS IMMUNOLOGICAL REGRESSION; RAT HISTIOCYTOMA; NK CELLS; LYMPHOCYTES; REJECTION; IMMUNITY;
Keywords:
NK CELL CYTOTOXICITY; TUMOR REGRESSION; CYTOKINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
A. Khar, "MECHANISMS INVOLVED IN NATURAL-KILLER-CELL MEDIATED TARGET-CELL DEATHLEADING TO SPONTANEOUS TUMOR-REGRESSION", Journal of Biosciences, 22(1), 1997, pp. 23-31

Abstract

We have studied the mechanisms involved in the spontaneous regressionof a rat histiocytoma in syngeneic hosts and tumour cell death processes, In addition to the natural killer (NX) cells which act through antibody dependent cellular cytotoxicity (ADCC), TNF-alpha also participates in the induction of necrosis in tumours, We have shown that the tumour cell is killed by necrosis which is perforin mediated, and apoptosis leading to target cell DNA fragmentation, A prior activation of the effector cells is essential before it can kill the target cell, as naive effector cells are ineffective, Activation of effector cells is mediated by Th1 type of cytokines in viro and in vivo. IFN-gamma seemsto play an important role in tumour regression as injection of antibodies to IFN-gamma in vivo inhibited tumour rejection.

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Documento generato il 02/06/20 alle ore 02:03:18