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Titolo:
Blood platelets are circulating stores for adhesive proteins, inflammatorymediators, and immunoglobulins - Role in nonhemolytic transfusion reactions
Autore:
Klinger, MHF; Kluter, H;
Indirizzi:
Univ Lubeck, Inst Immunol & Transfusionsmed, D-23538 Lubeck, Germany Univ Lubeck Lubeck Germany D-23538 nsfusionsmed, D-23538 Lubeck, Germany Univ Lubeck, Inst Anat, D-23538 Lubeck, Germany Univ Lubeck Lubeck Germany D-23538 k, Inst Anat, D-23538 Lubeck, Germany
Titolo Testata:
INFUSIONSTHERAPIE UND TRANSFUSIONSMEDIZIN
fascicolo: 1, volume: 26, anno: 1999,
pagine: 20 - 25
SICI:
1019-8466(199901)26:1<20:BPACSF>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SURFACE-ACTIVATED PLATELETS; RECEPTOR LIGAND COMPLEXES; OPEN CANALICULAR SYSTEM; GLYCOPROTEIN-IIB-IIIA; ALPHA-GRANULES; HUMAN MEGAKARYOCYTES; HUMAN EOSINOPHILS; HUMAN BASOPHILS; FIBRINOGEN; CYTOKINE;
Keywords:
nonhemolytic transfusion reactions; chemokines; cytokines; inflammation; platelets;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Kluter, H Univ Lubeck, Inst Immunol & Transfusionsmed, Ratzeburger Allee 160, D-23538 Univ Lubeck Ratzeburger Allee 160 Lubeck Germany D-23538 -23538
Citazione:
M.H.F. Klinger e H. Kluter, "Blood platelets are circulating stores for adhesive proteins, inflammatorymediators, and immunoglobulins - Role in nonhemolytic transfusion reactions", INFUSIONSTH, 26(1), 1999, pp. 20-25

Abstract

Objective: Blood platelets store within their alpha-granules a variety of substances that are involved in blood clotting, inflammation, and repair processes after a lesion of the vessel wall. Not all of these substances are synthesized within the megakaryocytes or platelets themselves, but some of them are taken up from the blood plasma by the circulating platelet. This article summarizes recent investigations on the internalization capabilitiesof platelets and the mechanism of endocytosis. Results: By means of immunoelectron microscopy and by incubations with gold-labeled peptides the uptake of fibrinogen, IgG, IgE, and the chemokine RANTES by the platelet. can be-demonstrated. Two different mechanisms.:of internalization are discerned: in resting platelets, the gold-labeled peptides are endocytosed and transferred to a-granules, whereas in platelets stimulated by ADP or thrombin the gold particles appear within the open canalicular system and not within granules. Conclusion: Platelets store and release not only proinflammatory mediatorsthat are typical for the megakaryocyte-platelet lineage,but also blood-borne substances from other cellular sources. Due to activation and disintegration of platelets that are stored as concentrates far usage in transfusion medicine, these substances can accumulate in the: platelet concentrate and might be responsible Tor transfusion-associated reactions. Further investigation in this field of platelet immunobiology is warranted.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 15:37:30