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Titolo:
D-1 RECEPTOR ACTIVATION ENHANCES EVOKED DISCHARGE IN NEOSTRIATAL MEDIUM SPINY NEURONS BY MODULATING AN L-TYPE CA2+ CONDUCTANCE
Autore:
HERNANDEZLOPEZ S; BARGAS J; SURMEIER DJ; REYES A; GALARRAGA E;
Indirizzi:
NATL AUTONOMOUS UNIV MEXICO,INST FISIOL CELULAR,DEPT BIOFIS,POB 70-253 MEXICO CITY 04510 DF MEXICO NATL AUTONOMOUS UNIV MEXICO,INST FISIOL CELULAR,DEPT BIOFIS MEXICO CITY 04510 DF MEXICO UNIV TENNESSEE,COLL MED,DEPT ANAT & NEUROBIOL MEMPHIS TN 38163
Titolo Testata:
The Journal of neuroscience
fascicolo: 9, volume: 17, anno: 1997,
pagine: 3334 - 3342
SICI:
0270-6474(1997)17:9<3334:DRAEED>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT STRIATAL NEURONS; CENTRAL-NERVOUS-SYSTEM; SYNAPTIC TRANSMISSION; DOPAMINE-RECEPTORS; PROJECTION NEURONS; MOLECULAR-BIOLOGY; SLICE PREPARATION; APICAL DENDRITES; PYRAMIDAL CELLS; CAUDATE-PUTAMEN;
Keywords:
DOPAMINE; NEUROMODULATION; FIRING PATTERNS; CALCIUM; NEOSTRIATUM, BASAL GANGLIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
69
Recensione:
Indirizzi per estratti:
Citazione:
S. Hernandezlopez et al., "D-1 RECEPTOR ACTIVATION ENHANCES EVOKED DISCHARGE IN NEOSTRIATAL MEDIUM SPINY NEURONS BY MODULATING AN L-TYPE CA2+ CONDUCTANCE", The Journal of neuroscience, 17(9), 1997, pp. 3334-3342

Abstract

Most in vitro studies of D-1 dopaminergic modulation of excitability in neostriatal medium spiny neurons have revealed inhibitory effects. Yet studies made in more intact preparations have shown that D-1 receptors can enhance or inhibit the responses to excitatory stimuli. One explanation for these differences is that the effects of D-1 receptors on excitability are dependent on changes in the membrane potential occurring in response to cortical inputs that are seen only in intact preparations. To test this hypothesis, we obtained voltage recordings from medium spiny neurons in slices and examined the impact of D-1 receptor stimulation at depolarized and hyperpolarized membrane potentials. As previously reported, evoked discharge was inhibited by D-1 agonistswhen holding at negative membrane potentials (approximately -80 mV). However, at more depolarized potentials (approximately -55 mV), D-1 agonists enhanced evoked activity. At these potentials, D-1 agonists or cAMP analogs prolonged or induced slow subthreshold depolarizations and increased the duration of barium- or TEA-induced Ca2+-dependent action potentials. Both effects were blocked by L-type Ca2+ channel antagonists (nicardipine, calciseptine) and were occluded by the L-type channel agonist BayK 8644-arguing that the D-1 receptor-mediated effects on evoked activity at depolarized membrane potential were mediated by enhancement of L-type Ca2+ currents. These results reconcile previous in vitro and in vivo studies by showing that D-1 dopamine receptor activation can either inhibit or enhance evoked activity, depending on thelevel of membrane depolarization.

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Documento generato il 21/09/20 alle ore 06:17:42