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Titolo:
GROUP-1 AND GROUP-2 METABOTROPIC GLUTAMATE RECEPTORS PLAY DIFFERENTIAL ROLES IN HIPPOCAMPAL LONG-TERM DEPRESSION AND LONG-TERM POTENTIATIONIN FREELY MOVING RATS
Autore:
MANAHANVAUGHAN D;
Indirizzi:
FED INST NEUROBIOL,DEPT NEUROPHYSIOL,BRENNECKESTR 6,POB 1860 D-39008 MAGDEBURG GERMANY
Titolo Testata:
The Journal of neuroscience
fascicolo: 9, volume: 17, anno: 1997,
pagine: 3303 - 3311
SICI:
0270-6474(1997)17:9<3303:GAGMGR>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MGLUR1 MUTANT MICE; PHENYLGLYCINE DERIVATIVES; MOLECULAR CHARACTERIZATION; SYNAPTIC TRANSMISSION; SIGNAL-TRANSDUCTION; PURKINJE-CELLS; AREA CA1; INDUCTION; LTP; EXPRESSION;
Keywords:
METABOTROPIC GLUTAMATE RECEPTORS; LONG-TERM DEPRESSION; LONG-TERM POTENTIATION; IN VIVO; HIPPOCAMPUS; NMDA RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
D. Manahanvaughan, "GROUP-1 AND GROUP-2 METABOTROPIC GLUTAMATE RECEPTORS PLAY DIFFERENTIAL ROLES IN HIPPOCAMPAL LONG-TERM DEPRESSION AND LONG-TERM POTENTIATIONIN FREELY MOVING RATS", The Journal of neuroscience, 17(9), 1997, pp. 3303-3311

Abstract

This study examined the role of metabotropic glutamate receptors (mGluRs) in hippocampal long-term depression (LTD) in vivo. The group 1 mGluR antagonist (S)4-carboxyphenylglycine (4CPG), group 1/2 antagonist (RS)-alpha-methyl-4-carboxyphenylglycine (MCPG), and group 2 antagonists (RS)-alpha-methylserine-O-phosphate monophenyl ester (MSOPPE) and (2S)-alpha-ethylglutamic acid (EGLU) were used. The NMDA receptor antagonist D(-)-2-amino-5-phosphonopentanoic acid (AP5) was used to examinethe NMDA receptor contribution to the observed LTD. Adult male Wistarrats underwent implantation of stimulating and recording electrodes into the Schaffer collaterals and CAI stratum radiatum, respectively, After recovery of 5-7 d, the field EPSP was measured from freely movinganimals. Drugs were applied either before or after 1 Hz low-frequencytrain (LFT) or 100 Hz stimulation via a cannula implanted in the lateral cerebral ventricle. Nine hundred pulses at 1 Hz produced an LTD that was marked and long-lasting, This LTD was completely inhibited by pre-LFT application of AP5, MCPG inhibited LTD from 2 hr post-LFT. 4CPGpartially impaired LTD. MSOPPE and EGLU completely blocked induction of LTD, although short-term depression remained intact. MSOPPE did notblock long-term potentiation (LTP) induced by 100 Hz stimulation, whereas 4CPG produced a significant inhibition. When MSOPPE was present, LTD could not be induced either before or after LTP induction, whereasLTD could be induced in an identical protocol in vehicle-injected animals. These results suggest a differential role for mGluRs in NMDA receptor-dependent hippocampal LTD in vivo. Group 1 mGluRs may play a role in both LTD and LTP, whereas group 2 mGluRs may be critically involved only in LTD induction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 18:27:06