Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Bradykinin-induced bronchospasm in the rat in vivo: a role for nitric oxide modulation
Autore:
Homma, T; Irvin, CG;
Indirizzi:
Univ Tsukuba, Inst Clin Med, Div Resp Dis, Tsukuba, Ibaraki 3058575, JapanUniv Tsukuba Tsukuba Ibaraki Japan 3058575 sukuba, Ibaraki 3058575, Japan Univarelorado, Hlth Sci Ctr, Natl Jewish Med Res Ctr, Div Pulm Sci & Crit C Univ Colorado Denver CO USA tl Jewish Med Res Ctr, Div Pulm Sci & Crit C Univ Colorado, Hlth Sci Ctr, Div Pulm Sci, Denver, CO USA Univ Colorado Denver CO USA , Hlth Sci Ctr, Div Pulm Sci, Denver, CO USA
Titolo Testata:
EUROPEAN RESPIRATORY JOURNAL
fascicolo: 2, volume: 13, anno: 1999,
pagine: 313 - 320
SICI:
0903-1936(199902)13:2<313:BBITRI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG TRACHEA; INDUCED BRONCHOCONSTRICTION; AIRWAY HYPERRESPONSIVENESS; INDUCED CONSTRICTION; SYNTHASE INHIBITOR; RELAXING FACTOR; L-ARGININE; IN-VIVO; LUNG; RELEASE;
Keywords:
airways; bradykinin; hyperresponsiveness; nitric oxide; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Homma, T Univ Tsukuba, Inst Clin Med, Div Resp Dis, Tsukuba, Ibaraki 3058575, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3058575 baraki 3058575, Japan
Citazione:
T. Homma e C.G. Irvin, "Bradykinin-induced bronchospasm in the rat in vivo: a role for nitric oxide modulation", EUR RESP J, 13(2), 1999, pp. 313-320

Abstract

Bradykinin has an important role in asthma pathogenesis, but its site of action is unclear. It was previously reported by the authors that bradykinincauses a dose-dependent reduction in dynamic compliance but little change in total lung resistance. This suggested that bradykinin may have a preferential effect in the distant lung. The purpose of the current investigation was to better characterize the effects of bradykinin on pulmonary resistance in rodents and explore the role of nitric oxide release in modulating theeffect of bradykinin,Airway constriction was induced in the rats by aerosol administration of bradykinin with or without treatments with the inhaled bradykinin-2 receptorantagonist, Hoe 140 or the nitric oxide synthase inhibitors N-G-nitro-L-arginine methylester or N-G-monomethyl-L-arginine. Total lung resistance was partitioned into tissue and airway resistance by using the alveolar capsulemethod. Bradykinin induced a significant increase in both resistances. Hoe 140 abolished the response to bradykinin. The nitric oxide synthase inhibitors enhanced the bronchoconstricting response,In conclusion, the bradykinin response in the rats was not only localized to conducting airways but also involved a relatively selective tissue reaction, Bradykinin-induced bronchospasm in the rat is solely due to activationof bradykinin-2 receptor, Further, it was shown that nitric oxide significantly modulates the bronchospasm caused by bradykinin, suggesting that nitric oxide is an important modulator of airways responsiveness to bradykinin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 19:57:14