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Titolo:
Effect of deramciclane, a new 5-HT receptor antagonist, on cholecystokinin-induced changes in rat gastrointestinal function
Autore:
Varga, G; Kordas, K; Burghardt, B; Gacsalyi, I; Szenasi, G;
Indirizzi:
Hungarian Acad Sci, Inst Expt Med, H-1450 Budapest, Hungary Hungarian AcadSci Budapest Hungary H-1450 Med, H-1450 Budapest, Hungary Semmelweis Univ Med, Dept Oral Biol, H-1085 Budapest, Hungary Semmelweis Univ Med Budapest Hungary H-1085 ol, H-1085 Budapest, Hungary Egis Pharmaceut, Div Preclin Res, H-1475 Budapest, Hungary Egis Pharmaceut Budapest Hungary H-1475 in Res, H-1475 Budapest, Hungary
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2-3, volume: 367, anno: 1999,
pagine: 315 - 323
SICI:
0014-2999(19990219)367:2-3<315:EODAN5>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PANCREATIC-SECRETION; CCK ANTAGONIST; INDUCED DELAY; GROWTH; LORGLUMIDE; CAMOSTATE; L-364,718; CERULEIN; PEPTIDE; NEURONS;
Keywords:
5-HT receptor; 5-HT (5-hydroxytryptamine, serotonin); CCK (cholecystokinin); pancreas; gastric emptying; gallbladder;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Varga, G Hungarian Acad Sci, Inst Expt Med, POB 67, H-1450 Budapest, Hungary Hungarian Acad Sci POB 67 Budapest Hungary H-1450 apest, Hungary
Citazione:
G. Varga et al., "Effect of deramciclane, a new 5-HT receptor antagonist, on cholecystokinin-induced changes in rat gastrointestinal function", EUR J PHARM, 367(2-3), 1999, pp. 315-323

Abstract

Recent studies suggested that serotonin receptors may be involved in modulating the actions of cholecystokinin (CCK) in the gastrointestinal tract. The present work was designed to compare the effects of deramciclane, a recently developed serotonin-2 (5-HT2A/2C) receptor antagonist, and lorglumide,a CCKA receptor antagonist, on exogenous and endogenous CCK-induced pancreatic enzyme secretion and pancreatic growth, as well as on the emptying of the stomach and the gallbladder. Pancreatic secretory function was tested while CCK release was evoked by diversion of bile-pancreatic juice in rats. Adaptive growth of the pancreas was induced by chronic intragastric administration of camostate, a potent synthetic trypsin inhibitor in rats. Gastricemptying of a noncaloric test meal was investigated in response to intraduodenal intralipid infusion, also in rats. In fasted mice, gallbladder emptying was examined in response to intragastric egg yolk administration. In rats, diversion of bile-pancreatic juice from the duodenum stimulated pancreatic amylase secretion. This action was blocked by deramciclane and by lorglumide. Pancreatic hypertrophy and hyperplasia induced by chronic camostate administration was also suppressed by both the serotonin- and the CCK-receptor antagonists. Intraduodenal administration of intralipid induced a significant delay in gastric emptying. This effect was inhibited by both deramciclane and lorglumide in rats. In mice? intragastric administration of egg yolk elicited an accelerated release of bile from the gallbladder. Prior treatment with either deramciclane or lorglumide abolished this response. Lorglumide was able to inhibit the functional responses elicited by exogenous CCK administration in both pancreas, stomach and gallbladder, while deramciclane was not effective under such circumstances. Our data show that deramciclane inhibited the effects of CCK on pancreatic, gastric and gallbladder function when its endogenous release was stimulated, but did not alter the effects of exogenously administered peptide. These results suggest that serotonin, primarily via 5-HT2A, receptors, may modulate CCK-mediated gastrointestinal functions in rats. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 18:03:35