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Titolo:
Effects of nocistatin on nociceptin-induced impairment of learning and memory in mice
Autore:
Hiramatsu, M; Inoue, K;
Indirizzi:
Meijochiiv, Fac Pharmaceut Sci, Dept Chem Pharmacol, Tempaku Ku, Nagoya, Ai Meijo Univ Nagoya Aichi Japan 4688503 m Pharmacol, Tempaku Ku, Nagoya, Ai
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2-3, volume: 367, anno: 1999,
pagine: 151 - 155
SICI:
0014-2999(19990219)367:2-3<151:EONONI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED DELAYED AMNESIA; LONG-TERM POTENTIATION; RAT HIPPOCAMPUS; ORPHANIN-FQ; DYNORPHIN; RECEPTOR; BRAIN; TASK;
Keywords:
nocistatin; nociceptin; orphanin FQ; dynorphin A; passive avoidance; learning; memory;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Hiramatsu, M Meijochiiv, Fac Pharmaceut Sci, Dept Chem Pharmacol, Tempaku Ku, Nagoya, Ai Meijo Univ Nagoya Aichi Japan 4688503 Tempaku Ku, Nagoya, Ai
Citazione:
M. Hiramatsu e K. Inoue, "Effects of nocistatin on nociceptin-induced impairment of learning and memory in mice", EUR J PHARM, 367(2-3), 1999, pp. 151-155

Abstract

We investigated the effects of nociceptin/orphanin FQ and nocistatin on learning and memory function as measured in a step-down type passive avoidance task and spontaneous alternation of Y-maze with mice. Nociceptin (0.5-5.0nmol/mouse, i.c.v.) 30 min before the training session or Y-maze test, dose dependently shortened the step-down latency and impaired spontaneous alternation, while there was no significant effect of nocistatin (0.5-5.0 nmol/mouse). interestingly, nocistatin (5.0 nmol) significantly improved the nociceptin (5.0 nmol)-induced impairment of learning and memory without changing motor activity or response to electric shocks. These results suggest that nocistatin, a new biologically active peptide now found to also counteract the impairment of learning and memory induced by nociceptin, plays an important role in the regulation of learning and memory process in the centralnervous system. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 12:03:24