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Titolo:
Morphogenetic roles of acetylcholine
Autore:
Lauder, JM; Schambra, UB;
Indirizzi:
Univ N Carolina, Sch Med, Dept Cell Biol & Anat, Chapel Hill, NC 27599 USAUniv N Carolina Chapel Hill NC USA 27599 Anat, Chapel Hill, NC 27599 USA Ehnsonessee State Univ, James H Quillen Coll Med, Dept Anat & Cell Biol, Jo E Tennessee State Univ Johnson City TN USA 37614 ept Anat & Cell Biol, Jo
Titolo Testata:
ENVIRONMENTAL HEALTH PERSPECTIVES
, volume: 107, anno: 1999, supplemento:, 1
pagine: 65 - 69
SICI:
0091-6765(199902)107:<65:MROA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCARINIC RECEPTOR SUBTYPES; CENTRAL-NERVOUS-SYSTEM; RAT VISUAL-CORTEX; GASTRULATING CHICK-EMBRYO; CHOLINE-ACETYLTRANSFERASE; HYBRIDIZATION HISTOCHEMISTRY; SOMATOSENSORY CORTEX; LAMINAR EXPRESSION; NICOTINE BINDING; GENE-EXPRESSION;
Keywords:
rodent; sea urchin; embryo; neurogenesis; brain development; Rett's syndrome; AChE; pesticides;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Lauder, JM Univ7599arolina, Sch Med, Dept Cell Biol & Anat, CB 7090, Chapel Hill, NC 2 Univ N Carolina CB 7090 Chapel Hill NC USA 27599 pel Hill, NC 2
Citazione:
J.M. Lauder e U.B. Schambra, "Morphogenetic roles of acetylcholine", ENVIR H PER, 107, 1999, pp. 65-69

Abstract

In the adult nervous system, neurotransmitters mediate cellular communication within neuronal circuits. In developing tissues and primitive organisms, neurotransmitters subserve growth regulatory and morphogenetic functions. Accumulated evidence suggests that acetylcholine, (ACh), released from growing axons, regulates growth, differentiation, and plasticity of developingcentral nervous system neurons. In addition to intrinsic cholinergic neurons, the cerebral cortex and hippocampus receive extensive innervation from cholinergic neurons in the basal forebrain, beginning prenatally and continuing throughout the period of active growth and synaptogenesis. Acute exposure to ethanol in early gestation (which prevents formation of basal forebrain cholinergic neurons) or neonatal lesioning of basal forebrain cholinergic neurons, significantly compromises cortical development and produces persistent impairment of cognitive functions. Neonatal visual deprivation alters developmental expression of muscarinic acetylcholine receptors (mAChR) in visual cortex, whereas local infusion of mAChR antagonists impairs plasticity of visual cortical neurons. These findings raise the possibility that exposure to environmental neurotoxins that affect cholinergic systems may seriously compromise brain development and have long-lasting morphologic, neurochemical, and functional consequences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:10:52